How To Use Estradiol

Oral estradiol comes in the form of a tablet to be taken by mouth 1-3 times daily. Taking this medication with food may help to reduce nausea. Try to take your medicine at around the same time(s) every day.

When estradiol is prescribed to menopausal women who have a uterus, another female sex hormone, progestin, is also prescribed to lower the risk of endometrial cancer. Women who do not have a uterus do not need progestin. 

Estradiol alone or in combination with progestin is prescribed at the lowest effective dose for the shortest time possible. Your doctor will reevaluate you periodically at 3- or 6-month intervals to determine if estradiol treatment is still required. If you have a uterus, your doctor will order diagnostic tests, such as endometrial sampling, for early detection of endometrial cancer and to rule out cancer if you have unusual vaginal bleeding. 

Read the prescription label carefully. Follow your doctor’s dosing instructions and take estradiol exactly as prescribed. Do not change the dose or dosing frequency without your doctor’s approval.

Missed dose: If you miss a dose of estradiol, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next dose according to your regular dosing schedule. Do not take a double dose or extra medicine to make up for a missed dose.

Storage: Store estradiol at room temperature (between 15-30° C or 59-86° F) away from moisture, heat, and direct light in its original container, tightly closed. Do not store medications in the bathroom, where they can be exposed to moisture and heat. Keep all medications safely out of reach of children and pets.

Unused medicine: Unused or expired estradiol should be disposed of in a way that children, other people, and pets cannot get to them. Do not throw estradiol in the trash or flush it down the toilet. The best way to dispose of expired or unneeded estradiol is through your local waste disposal company or a drug take-back program. Learn more about proper medication disposal. 

NOTE: This medication guide is a summary and may not contain all possible drug information on estradiol. The information contained here may not be up-to-date. This sheet is for information purposes only. If you have questions about estradiol, talk to your healthcare professionals for medical advice.

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