Do not take this medicine with any of the following medications:

-avanafil
-defibrotide
-itraconazole
This medicine may also interact with the following medications:

-aspirin
-certain antibiotics like clarithromycin, telithromycin, and rifampin
-certain antiviral medicines for HIV or AIDS like atazanavir, indinavir, nelfinavir, ritonavir, and saquinavir
-certain medicines for cholesterol like lovastatin and simvastatin
-certain medicines for fungal infections like itraconazole, ketoconazole and voriconazole
-certain medicines for seizures like carbamazepine, phenobarbital, and phenytoin
-digoxin
-narcotic medicines for pain
-nefazodone

They need to know if you have any of these conditions:

-bleeding disorders
-bleeding in the brain
-colon polyps
-having surgery
-history of irregular heartbeat or rhythm
-history of stomach bleeding
-liver disease
-lung or breathing disease (asthma, COPD)
-severe injury
-sleep apnea
-stomach ulcer
-stroke or transient ischemic attack
-take medicines that treat or prevent blood clots
-an unusual or allergic reaction to ticagrelor, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Your condition will be monitored carefully while you are receiving this medicine. It is important not to miss any appointments.
This medicine may increase your risk to bruise or bleed. Call your health care provider if you notice any unusual bleeding.
Avoid sports or activities that might cause injury while you are using this medicine. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your health care provider.
If you are going to have surgery or other procedure, tell your health care provider that you are taking this medicine.
Tell your dentist and dental surgeon that you are taking this medicine. You should not have major dental surgery while on this medicine. See your dentist to have a dental exam and fix any dental problems before starting this medicine. Take good care of your teeth while on this medicine. Make sure to see your dentist for regular cleanings.
You should take aspirin every day with this medicine. Do not take more than 100 mg of aspirin per day.
Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medicines and doses you take on the card.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.