Warnings


What may interact with COMETRIQ?

This medicine may interact with the following medications:

-atazanavir
-carbamazepine
-clarithromycin
-conivaptan
-grapefruit juice
-indinavir
-itraconazole
-ketoconazole
-nefazodone
-nelfinavir
-phenobarbital
-phenytoin
-rifabutin
-rifampin
-rifapentine
-ritonavir
-saquinavir
-St. John''s Wort
-telithromycin
-voriconazole

What should I tell my health care provider before I take COMETRIQ?

They need to know if you have any of these conditions:

-bleeding disorders
-high blood pressure
-liver disease
-recent surgery
-skin conditions or sensitivity
-an unusual or allergic reaction to cabozantinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using COMETRIQ?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
Before having surgery or dental work, talk to your health care provider to make sure it is ok. This drug can increase the risk of poor healing of your surgical site or wound. You will need to stop this drug for 3 weeks before surgery. After surgery, wait at least 2 weeks weeks before restarting this drug. Make sure the surgical site or wound is healed enough before restarting this drug. Talk to your health care provider if questions.
Do not become pregnant while taking this medicine or for 4 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 4 months after the last dose.
This medicine may interfere with the ability to have a child. You should talk with your doctor or health care professional if you are concerned about your fertility.

Where should I keep my medicine?

Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.