What side effects may I notice from receiving Cotellic?

Side effects that you should report to your doctor or health care professional as soon as possible:

-changes in skin including blistering, peeling of the skin
-changes in vision including blurred vision
-fast heartbeat
-shortness of breath
-signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-signs and symptoms of muscle injury like dark urine; trouble passing urine or change in the amount of urine; unusually weak or tired; muscle pain or side or back pain; muscle weakness
-swelling of the ankles, feet, hands

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-diarrhea
-fever

This list may not describe all possible side effects for Cotellic. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.