bupropion-hcl

Medically Reviewed by HaVy Ngo, Pharm.D.

Last Reviewed: Jun 07, 2022

Pros & Cons


What are the pros and cons of bupropion (Wellbutrin XL)?

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  • Available as a generic at a lower price
  • Effective in treating depression as a monotherapy or in combination with other antidepressants
  • An affordable alternative for people who have not had positive outcomes with other antidepressant classes such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Has fewer sexual side effects than other antidepressants
  • Weight gain is not as prevalent as a side effect as other antidepressants

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  • Not a safe option for people who have seizures or eating disorders
  • Takes several weeks to see the full effects
  • Must avoid or limit the amount of alcohol consumed during treatment 
  • May cause sleeping problems if it is being taken later on during the day