Chlorhexidine Gluconate

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jul 11, 2022

Uses


What is Chlorhexidine used for?

Peridex (chlorhexidine gluconate 0.12%) is a prescription mouthwash that provides antimicrobial activity during oral rinsing. It is used to treat periodontal disease, specifically gingivitis (inflammation of the gums) and gingival bleeding (gum bleeding). It may help ease symptoms of mouth ulcers (sores inside the mouth). 

There may be other uses of chlorhexidine gluconate — your healthcare professional or pharmacist can provide medical advice and give you more chlorhexidine drug information.

Chlorhexidine Mechanism of Action

Chlorhexidine affects the oral microbial ecosystem by slowing bacterial growth and killing bacteria. Studies on clinical effectiveness have shown that using chlorhexidine for 6 months can significantly reduce the counts of plaque bacteria in the mouth.

What is the dosage of Chlorhexidine?

Peridex contains chlorhexidine gluconate 0.12% and is available in 118 mL, 473 mL, and 1893 mL bottles. The usual dose of chlorhexidine is one capful (15 mL) to be swished in the oral cavity twice a day for 30 seconds and then spit out. Chlorhexidine should not be swallowed.