Auvi-Q

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Mar 28, 2024

epinephrine Drug Details (Generic)


Generic Name:

Epinephrine

Common Brands:

EpiPen Auto-Injector, EpiPen Jr. Auto-Injector, Adrenalin, Adrenaclick, Auvi-Q, Symjepi

Availability:

Prescription only

Therapeutic Class:

Sympathomimetic agents (alpha and beta-adrenergic agonists)

Forms:

Intravenous injection solution, prefilled automatic injection device

Administration:

By subcutaneous, intramuscular, or intravenous injection

Therapeutic Uses:

  • Life-threatening allergic reactions, including anaphylaxis (throat closing)
  • Low blood pressure in adults with septic shock
  • To induce and maintain mydriasis (dilation of the pupil) during eye surgery

Controlled Status:

Not a controlled substance


Epinephrine Drug Class

Epinephrine (eh-pee-nef-rin) belongs to a group of drugs called alpha and beta-adrenergic agonists (sympathomimetic agents). It is also called adrenaline and is made by the adrenal medulla (the inner part of the adrenal gland). The adrenal glands are hat-shaped glands that sit on top of each kidney. Epinephrine (adrenaline) is one of the naturally occurring hormones that play a key role in the body’s fight-or-flight response.

Epinephrine Age Range

Epinephrine is approved for use in adults and children. However, the safety and effectiveness of this medication in pediatric patients with septic shock have not been established.

Primatene Mist Drug Details (Brand)


Generic Name:

Therapeutic Class:

Asthma and Respiratory

Availability:

OTC

Common Brands:

Form:

Pressurized inhalation, solution

EPINEPHRINE (ep i NEF rin) helps open up air passages and makes breathing easier for people with mild asthma.

EpiPen 2-Pak Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

Epinephine Professional EMS Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

EpinephrineSnap Drug Details (Brand)


Generic Name:

Therapeutic Class:

Heart Health

Availability:

Rx

Common Brands:

Form:

Solution for injection

EPINEPHRINE (ep i NEF rin) is used for the emergency treatment of severe allergic reactions. You should keep this medicine with you at all times.

EpiPen Jr 2-Pak Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

EpinephrineSnap-V Drug Details (Brand)


Generic Name:

Therapeutic Class:

Heart Health

Availability:

Rx

Common Brands:

Form:

Solution for injection

EPINEPHRINE (ep i NEF rin) is used for the emergency treatment of severe allergic reactions. You should keep this medicine with you at all times.

Adyphren Amp II Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

Adrenalin Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Rx

Common Brands:

Form:

Nasal spray, solution|Solution for injection

EPINEPHRINE (ep i NEF rin) can help to open up air passages and make breathing easier for people with various lung problems such as severe asthma. It also treats severe allergic reactions and certain heart problems. This medicine is sometimes added to certain types of anesthesia to make them last longer.

Adyphren II Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

Epinephrine Professional Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

Adyphren Amp Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

Symjepi Drug Details (Brand)


Generic Name:

Therapeutic Class:

Heart Health

Availability:

Rx

Common Brands:

Form:

Solution for injection

EPINEPHRINE (ep i NEF rin) is used for the emergency treatment of severe allergic reactions. You should keep this medicine with you at all times.

Auvi-Q Drug Details (Brand)


Generic Name:

Therapeutic Class:

Heart Health

Availability:

Rx

Common Brands:

Form:

Solution for injection

EPINEPHRINE (ep i NEF rin) is used for the emergency treatment of severe allergic reactions. You should keep this medicine with you at all times.

EpiPen Drug Details (Brand)


Generic Name:

Therapeutic Class:

Heart Health

Availability:

Rx

Common Brands:

Form:

Solution for injection

EPINEPHRINE (ep i NEF rin) is used for the emergency treatment of severe allergic reactions. You should keep this medicine with you at all times.

Adyphren Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

EPIsnap Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

neffy Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

EpinephrineSnap-EMS Drug Details (Brand)


Generic Name:

Therapeutic Class:

Availability:

Common Brands:

Form:

epinephrine Uses (Generic)


Epinephrine Uses

Epinephrine is used for emergency treatment of severe allergic reactions in adults and children caused by foods, drugs, insect stings, and other allergens. This drug is also used to dilate (widen) the pupil during intraocular (eye) surgery in adults and children. It is also used to increase blood pressure in adult patients with hypotension (low blood pressure) due to septic shock (a serious widespread infection). Other uses of epinephrine may include cardiopulmonary resuscitation in cardiac arrest and to relax the smooth muscle in the airways during severe asthma exacerbations. 

There may be other uses of epinephrine—your doctor or health system pharmacists can give you further drug information.

Epinephrine Mechanism of Action

Epinephrine acts on both alpha-adrenergic receptors and beta-adrenergic receptors in the sympathetic nervous system. It relaxes the smooth muscle of the airways, making it easier to breathe. It also tightens blood vessels and affects blood flow in various organs. Epinephrine leads to contraction of the dilator muscles in the pupils, thereby dilating or widening the pupils. When given by intravenous injection, epinephrine causes a rapid increase in systolic blood pressure and heart rate. It also stimulates the heart muscle and increases the strength of ventricular contraction. This drug causes constriction (narrowing) of the small blood vessels in the skin and mucosa, which can help reduce swelling and hives associated with allergic reactions. Epinephrine also stimulates glycogenolysis in the liver, which leads to increased blood sugar levels and provides immediate energy.

Epinephrine Doses

The prefilled automatic injection device contains a single fixed dose of epinephrine. EpiPen Auto-Injector contains 0.3 mg epinephrine injection (0.3 mL, 1:1000) for use by people weighing 30 kg (66 pounds) or more. The EpiPen Jr Auto-Injector contains 0.15 mg epinephrine injection (0.3 mL, 1:2000) for use by people weighing 15 to 30 kg (33 - 66 pounds).

You may need to take more than one dose of epinephrine for a severe or persistent life-threatening allergic reaction such as anaphylaxis. More than two sequential epinephrine doses should only be given under direct medical supervision.

epinephrine Directions (Generic)


How To Use Epinephrine

Epinephrine comes in the form of a prefilled automatic injection device that contains a single dose for subcutaneous injection (under the skin) or intramuscular injection (into a muscle). It should be injected in the middle or outer part of the thigh. This medicine can be injected through clothing, if necessary. 

Do not inject the medicine into any other part of the body, such as the buttocks, hands, or feet, or into a vein. Seek emergency medical treatment if you accidentally inject epinephrine anywhere except the thigh. If you are giving epinephrine to a young child, hold their leg firmly in place to prevent movement before and during the injection. Do not put your fingers, thumb, or hand over the needle of the automatic injection device. 

Epinephrine should be used at the first sign of an allergic reaction. Symptoms of serious allergic reactions can include anaphylaxis (airway closing), wheezing, hoarseness, sneezing, skin rash, skin redness, hives, itching, swelling of the eyes, lips, throat, or hands, weak pulse, fast heartbeat, confusion, anxiety, stomach pain, diarrhea, vomiting, loss of bowel or bladder control, fainting, and seizures. Ensure you can recognize the symptoms of a serious allergic reaction as well as when to inject epinephrine.

Read the prescription label carefully and use epinephrine exactly as prescribed. Do not use a higher or lower dose or use the drug other than as advised by your healthcare provider.

Read the patient information leaflet and make sure you understand the correct use of the prefilled automatic injection device. Your doctor or pharmacist can also show you and your caregivers how to use this device. You can also obtain training devices to practice (these training devices do not have a needle and do not contain medication). 

Always keep two automatic injection devices easily accessible at all times. Most epinephrine injection devices contain a single dose of the medicine. You may need to use more than one dose to treat a severe life-threatening allergic reaction if your symptoms do not improve or come back after the first injection. Make sure you understand when to use a second dose. You should not use more than two doses of epinephrine to treat a single episode of an allergic reaction - only healthcare professionals can do so.

Make a note of the expiry date on the injection device and replace it before the medicine expires. Visually inspect the solution in the injection device periodically and make sure there are no particles in it and it is not discolored. If you see particles floating in the solution or it has turned a pinkish or darker yellow color, contact your healthcare provider immediately for a replacement. The drug may not be effective if it has particles or is discolored.

Remember that epinephrine injection is for emergency treatment of serious allergic reactions; however, it is not a substitute for professional medical treatment. After injecting epinephrine, seek medical care. 

It is common to see some remaining medicine in the injection device after a dose. This does not indicate that you received less than the full dose. You don’t need to take another dose if this is the case. Keep the used injection device to show to the emergency department physicians. Ask your pharmacist or doctor about the safe disposal of used epinephrine injections.

Missed dose: Epinephrine administration is done as needed to treat a life-threatening allergic reaction.

Storage: Store epinephrine prefilled automatic injection devices at room temperature (between 15-30° C or 59-86° F) away from moisture, heat, and direct light in their original container, tightly closed. Do not store this medicine in the refrigerator. Do not leave the medicine in your car, where it can be exposed to extreme hot or cold temperatures. Do not store medications in the bathroom, where they can be exposed to moisture and heat. Keep all medications safely out of reach of children and pets. If you drop a prefilled automatic injection device, check to make sure it is not damaged. Request a replacement if you notice a crack or leakage.

Unused medicine: Unused or expired epinephrine should be disposed of in a way that children, other people, and pets cannot get to them. Do not throw epinephrine in the trash or flush it down the toilet. The best way to dispose of expired or unneeded epinephrine is through your local waste disposal company or a drug take-back program. Learn more about proper medication disposal

NOTEThis medication guide is a summary and may not contain all possible drug information on epinephrine. The information contained here may not be up-to-date. This sheet is for information purposes only. If you have questions about epinephrine, talk to your healthcare professionals for medical advice.


Card

Discounted prices for epinephrine
 start at $250.35.


Get your FREE BuzzRx card and 
start saving today!


Primatene Mist Directions (Brand)


How should I use Primatene Mist?

This medicine is for inhalation through the mouth. Follow the directions on the package label. Do not use more often than directed. Make sure that you are using your inhaler correctly. Ask you doctor or health care provider if you have any questions.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be used in children as young as 12 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of Primatene Mist contact a poison control center or emergency room at once. NOTE: Primatene Mist is only for you. Do not share Primatene Mist with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

EpiPen 2-Pak Directions (Brand)


Epinephine Professional EMS Directions (Brand)


EpinephrineSnap Directions (Brand)


How should I use epinephrinesnap ?

This medicine is for injection into the outer thigh. Your doctor or health care professional will instruct you on the proper use of the device during an emergency. Read all directions carefully and make sure you understand them. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This drug is commonly used in children. A special device is available for use in children. If you are giving this medicine to a young child, hold their leg firmly in place before and during the injection to prevent injury.

Overdosage: If you think you have taken too much of epinephrinesnap contact a poison control center or emergency room at once. NOTE: epinephrinesnap is only for you. Do not share epinephrinesnap with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

EpiPen Jr 2-Pak Directions (Brand)


EpinephrineSnap-V Directions (Brand)


How should I use epinephrinesnap ?

This medicine is for injection into the outer thigh. Your doctor or health care professional will instruct you on the proper use of the device during an emergency. Read all directions carefully and make sure you understand them. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This drug is commonly used in children. A special device is available for use in children. If you are giving this medicine to a young child, hold their leg firmly in place before and during the injection to prevent injury.

Overdosage: If you think you have taken too much of epinephrinesnap contact a poison control center or emergency room at once. NOTE: epinephrinesnap is only for you. Do not share epinephrinesnap with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Adyphren Amp II Directions (Brand)


Adrenalin Directions (Brand)


How should I use Adrenalin?

This medicine is for injection under the skin, into a muscle or into a vein. It is given by a health care professional in a clinic or hospital setting.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of Adrenalin contact a poison control center or emergency room at once. NOTE: Adrenalin is only for you. Do not share Adrenalin with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Adyphren II Directions (Brand)


Epinephrine Professional Directions (Brand)


Adyphren Amp Directions (Brand)


Symjepi Directions (Brand)


How should I use SYMJEPI?

This medicine is for injection into the outer thigh. Your doctor or health care professional will instruct you on the proper use of the device during an emergency. Read all directions carefully and make sure you understand them. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This drug is commonly used in children. A special device is available for use in children. If you are giving this medicine to a young child, hold their leg firmly in place before and during the injection to prevent injury.

Overdosage: If you think you have taken too much of SYMJEPI contact a poison control center or emergency room at once. NOTE: SYMJEPI is only for you. Do not share SYMJEPI with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Auvi-Q Directions (Brand)


How should I use Auvi-Q?

This medicine is for injection into the outer thigh. Your doctor or health care professional will instruct you on the proper use of the device during an emergency. Read all directions carefully and make sure you understand them. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This drug is commonly used in children. A special device is available for use in children. If you are giving this medicine to a young child, hold their leg firmly in place before and during the injection to prevent injury.

Overdosage: If you think you have taken too much of Auvi-Q contact a poison control center or emergency room at once. NOTE: Auvi-Q is only for you. Do not share Auvi-Q with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

EpiPen Directions (Brand)


How should I use EpiPen?

This medicine is for injection into the outer thigh. Your doctor or health care professional will instruct you on the proper use of the device during an emergency. Read all directions carefully and make sure you understand them. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This drug is commonly used in children. A special device is available for use in children. If you are giving this medicine to a young child, hold their leg firmly in place before and during the injection to prevent injury.

Overdosage: If you think you have taken too much of EpiPen contact a poison control center or emergency room at once. NOTE: EpiPen is only for you. Do not share EpiPen with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Adyphren Directions (Brand)


EPIsnap Directions (Brand)


neffy Directions (Brand)


EpinephrineSnap-EMS Directions (Brand)


epinephrine Side Effects (Generic)


Epinephrine Side Effects

Common side effects of epinephrine are listed below. Tell your doctor if these side effects are severe when you obtain emergency medical care after an allergic reaction.

  • Injection site reaction with skin redness, swelling, tenderness, or warmth
  • Fast, pounding, or irregular heartbeat
  • Difficulty breathing
  • Dizziness
  • Sweating
  • Nausea
  • Vomiting
  • Restlessness, nervousness, or anxiety
  • Pale skin
  • Weakness
  • Uncontrolled shaking
  • Headache

The above list may not include all the potential adverse effects of epinephrine. Contact your healthcare professional if the side effects are unusual or severe or they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Epinephrine Overdose: In case of an overdose, call your doctor immediately. You can also call your local poison control center or the national poison control center at 1-800-222-1222. Call 911 if a person cannot be awakened, has trouble breathing, has collapsed, or has had a seizure. Signs and symptoms of an epinephrine overdose may include pale or cold skin, tiredness, sudden weakness or numbness on one side of the body, confusion, sudden problems with speaking, fast breathing, shortness of breath, and decreased urination.

Source: FDA


Primatene Mist Side Effects (Brand)


What side effects may I notice from receiving Primatene Mist?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-chest pain
-fast heartbeat
-high blood pressure
-nervousness
-palpitations
-seizures
-tremor
-trouble passing urine or change in the amount of urine
-trouble sleeping
-vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-headache
-nausea

This list may not describe all possible side effects for Primatene Mist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

EpiPen 2-Pak Side Effects (Brand)


Source: FDA

Epinephine Professional EMS Side Effects (Brand)


Source: FDA

EpinephrineSnap Side Effects (Brand)


What side effects may I notice from receiving epinephrinesnap ?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-chest pain
-fast, irregular heartbeat
-pain, tingling, numbness in the hands or feet
-pain, redness, or irritation at site where injected
-vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-anxious
-dizziness
-dry mouth
-headache
-increased sweating
-nausea
-unusually weak or tired

This list may not describe all possible side effects for epinephrinesnap . Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

EpiPen Jr 2-Pak Side Effects (Brand)


Source: FDA

EpinephrineSnap-V Side Effects (Brand)


What side effects may I notice from receiving epinephrinesnap ?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-chest pain
-fast, irregular heartbeat
-pain, tingling, numbness in the hands or feet
-pain, redness, or irritation at site where injected
-vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-anxious
-dizziness
-dry mouth
-headache
-increased sweating
-nausea
-unusually weak or tired

This list may not describe all possible side effects for epinephrinesnap . Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

Adyphren Amp II Side Effects (Brand)


Source: FDA

Adrenalin Side Effects (Brand)


What side effects may I notice from receiving Adrenalin?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-chest pain
-fast, irregular heartbeat
-pain, tingling, numbness in the hands or feet
-pain, redness, or irritation at site where injected
-vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-anxious
-dry mouth
-dizziness
-headache
-increased sweating
-nausea
-weakness or tiredness

This list may not describe all possible side effects for Adrenalin. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

Adyphren II Side Effects (Brand)


Source: FDA

Epinephrine Professional Side Effects (Brand)


Source: FDA

Adyphren Amp Side Effects (Brand)


Source: FDA

Symjepi Side Effects (Brand)


What side effects may I notice from receiving SYMJEPI?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-chest pain
-fast, irregular heartbeat
-pain, tingling, numbness in the hands or feet
-pain, redness, or irritation at site where injected
-vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-anxious
-dizziness
-dry mouth
-headache
-increased sweating
-nausea
-unusually weak or tired

This list may not describe all possible side effects for SYMJEPI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

Auvi-Q Side Effects (Brand)


What side effects may I notice from receiving Auvi-Q?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-chest pain
-fast, irregular heartbeat
-pain, tingling, numbness in the hands or feet
-pain, redness, or irritation at site where injected
-vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-anxious
-dizziness
-dry mouth
-headache
-increased sweating
-nausea
-unusually weak or tired

This list may not describe all possible side effects for Auvi-Q. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

EpiPen Side Effects (Brand)


What side effects may I notice from receiving EpiPen?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-chest pain
-fast, irregular heartbeat
-pain, tingling, numbness in the hands or feet
-pain, redness, or irritation at site where injected
-vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-anxious
-dizziness
-dry mouth
-headache
-increased sweating
-nausea
-unusually weak or tired

This list may not describe all possible side effects for EpiPen. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

Adyphren Side Effects (Brand)


Source: FDA

EPIsnap Side Effects (Brand)


Source: FDA

neffy Side Effects (Brand)


Source: FDA

EpinephrineSnap-EMS Side Effects (Brand)


Source: FDA

epinephrine Warnings (Generic)


Epinephrine Risks, Warnings, and Complications


  • FOR INJECTION INTO THE THIGH ONLY: You should only use the auto-injectors containing epinephrine in the anterolateral thigh (middle or side of the thigh). Do not inject this medicine into the buttock. It may not work effectively to treat anaphylactic reactions if you do so. Injecting this medicine into the hands or feet may cause narrowing of the blood vessels and reduced blood flow to the area, requiring treatment. Go to the nearest emergency room immediately for further treatment if you accidentally inject epinephrine into any part of the body other than the thigh.

    Also, epinephrine should not be injected intravenously (into a vein). Large doses or accidental intravenous injection can result in dangerously high blood pressure and cerebral hemorrhage (bleeding in the brain). In case of accidental intravenous injection, seek emergency care. 

    Note that you may be administered epinephrine intravenously in a healthcare setting by trained healthcare providers for anaphylactic reactions or cardiac arrest. Nebulized epinephrine may be used to treat asthma exacerbations, bronchospasm (narrowing of the airways), stridor, croup, and laryngeal or pharyngeal edema (swelling).

  • SULFITE ALLERGY: Epinephrine formulations contain sodium metabisulfite, which can cause allergic-type reactions, including asthmatic episodes and life-threatening anaphylaxis in certain people. Nonetheless, epinephrine is still the preferred treatment for serious hypersensitivity reactions in emergency situations because the alternatives are not satisfactory. If you have a sulfite allergy, do not avoid using epinephrine to treat serious allergic reactions in emergency situations.

  • RISK IN PEOPLE WITH HEART PROBLEMS: Epinephrine should be used with caution in people with heart disease, including cardiac arrhythmias (heart rhythm abnormalities), coronary artery disease, and hypertension (high blood pressure). It should also be used with caution in people who are taking medications that can increase the risk of heart arrhythmias, for example, digitalis, diuretics (water pills), and antiarrhythmic agents. In such individuals, epinephrine may cause or worsen angina pectoris (chest pain) or cause ventricular arrhythmias. However, the presence of these conditions is not a contraindication to the use of epinephrine in life-threatening situations.

  • STORAGE: Epinephrine should be stored away from light in the provided carrier tube at 25°C (77°F) (it can be stored at temperature ranges of 15°C-30°C (59°F-86°F). Do not refrigerate the epinephrine auto-injector devices. Before using the device, make sure the solution in the auto-injector is clear of particles and is not discolored. Obtain a replacement if the solution is discolored or contains particles.


Precautions Before Starting Epinephrine

Tell your doctor if you have had allergic reactions in the past to epinephrine, sulfites, any of the active or inactive ingredients in epinephrine injection, or any other drugs. Your doctor may tell you to take epinephrine even if you are allergic to any of the ingredients because it is a life-saving drug. 

Give your doctor or pharmacist a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, supplements, and herbal products. This can help avoid possible interactions between epinephrine and your other medications.

Epinephrine may not be safe for people with certain health conditions. Give your doctor your complete medical history, especially high blood pressure, chest pain, irregular heartbeat, diabetes, asthma, hyperthyroidism (overactive thyroid), Parkinson’s disease, or depression. 

Tell your doctor if you are pregnant, could be pregnant, are planning a pregnancy, or are breast-feeding.

Precautions During Use of Epinephrine

Do not start any new medications without checking with your healthcare provider.

Talk to your healthcare professional before using epinephrine injection if you become pregnant.

Epinephrine Drug Interactions

Taking epinephrine with certain other drugs can affect how the medicines work. Possible interactions between epinephrine and other medicines can increase the risk of serious adverse effects. Your doctor may change the dose of your medications, switch you to a different medication, or monitor you carefully for side effects if there are known interactions between epinephrine and your other medicines. Epinephrine can have drug interactions with the following medications:

  • Antihistamines such as diphenhydramine (Benadryl) and chlorpheniramine (Chlor-Trimeton)

Give your health care professional a complete list of all the medications you are taking, including prescription drugs, non-prescription medicines, dietary supplements, and herbal products. Also, tell your healthcare provider if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription and over-the-counter medicines.

Primatene Mist Warnings (Brand)


What may interact with Primatene Mist?

Do not take this medicine with any of the following medications:

-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-medicines for allergy, cold and cough
-other asthma medicines
-procarbazine
-stimulant medicines for attention disorders, weight loss, or to stay awake

This medicine may also interact with the following medications:

-caffeine
-certain medicines for depression, anxiety, or psychotic disturbances

What should I tell my health care provider before I take Primatene Mist?

They need to know if you have any of the following conditions:

-diabetes
-ever been hospitalized for asthma
-glaucoma
-heart disease
-high blood pressure
-mental illness
-prostate disease
-seizures
-thyroid disease
-taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
-tobacco smoker
-an unusual or allergic reaction to epinephrine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using Primatene Mist?

Do not use this medicine unless your doctor has told you that you have asthma.

Check with your doctor or health care professional if your symptoms do not start to get better within 20 minutes of inhalation, or if they get worse. You should also contact your doctor or health care professional if you need to use this medicine more than 8 times in 1 day or if you have more than 2 asthma attacks in 1 week.

Do not treat yourself for coughs, colds or allergies without checking with your doctor or health care professional. Some products may contain ingredients that will increase the effects of your medicine.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). The contents are under pressure and may burst when exposed to heat or flame. Throw away any unused medicine after the expiration date.

EpiPen 2-Pak Warnings (Brand)


Epinephine Professional EMS Warnings (Brand)


EpinephrineSnap Warnings (Brand)


What may interact with epinephrinesnap ?

This medicine is only used during an emergency. Significant drug interactions are not likely during emergency use.

What should I tell my health care provider before I take epinephrinesnap ?

They need to know if you have any of the following conditions:
-diabetes
-heart disease
-high blood pressure
-lung or breathing disease, like asthma
-Parkinson''s disease
-thyroid disease
-an unusual or allergic reaction to epinephrine, sulfites, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using epinephrinesnap ?

Keep this medicine ready for use in the case of a severe allergic reaction. Make sure that you have the phone number of your doctor or health care professional and local hospital ready. Remember to check the expiration date of your medicine regularly. You may need to have additional units of this medicine with you at work, school, or other places. Talk to your doctor or health care professional about your need for extra units. Some emergencies may require an additional dose. Check with your doctor or a health care professional before using an extra dose.

After use, go to the nearest hospital or call 911. Avoid physical activity. Make sure the treating health care professional knows you have received an injection of this medicine. You will receive additional instructions on what to do during and after use of this medicine before a medical emergency occurs.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and heat. The solution should be clear in color. If the solution is discolored or contains particles it must be replaced. Throw away any unused medicine after the expiration date. Ask your doctor or pharmacist about proper disposal of the injector if it is expired or has been used. Always replace your auto-injector before it expires.

EpiPen Jr 2-Pak Warnings (Brand)


EpinephrineSnap-V Warnings (Brand)


What may interact with epinephrinesnap ?

This medicine is only used during an emergency. Significant drug interactions are not likely during emergency use.

What should I tell my health care provider before I take epinephrinesnap ?

They need to know if you have any of the following conditions:
-diabetes
-heart disease
-high blood pressure
-lung or breathing disease, like asthma
-Parkinson''s disease
-thyroid disease
-an unusual or allergic reaction to epinephrine, sulfites, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using epinephrinesnap ?

Keep this medicine ready for use in the case of a severe allergic reaction. Make sure that you have the phone number of your doctor or health care professional and local hospital ready. Remember to check the expiration date of your medicine regularly. You may need to have additional units of this medicine with you at work, school, or other places. Talk to your doctor or health care professional about your need for extra units. Some emergencies may require an additional dose. Check with your doctor or a health care professional before using an extra dose.

After use, go to the nearest hospital or call 911. Avoid physical activity. Make sure the treating health care professional knows you have received an injection of this medicine. You will receive additional instructions on what to do during and after use of this medicine before a medical emergency occurs.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and heat. The solution should be clear in color. If the solution is discolored or contains particles it must be replaced. Throw away any unused medicine after the expiration date. Ask your doctor or pharmacist about proper disposal of the injector if it is expired or has been used. Always replace your auto-injector before it expires.

Adyphren Amp II Warnings (Brand)


Adrenalin Warnings (Brand)


What may interact with Adrenalin?

Do not take this medicine with any of the following medications:
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-medicines for colds and breathing difficulties
-medicines for hay fever and other allergies
-procarbazine
-stimulants like those used for weight loss or ADHD

This medicine may also interact with the following medications:
-digoxin
-diuretics
-tricyclic antidepressants like amitriptyline, desipramine, nortriptyline and others

What should I tell my health care provider before I take Adrenalin?

They need to know if you have any of the following conditions:
-blood vessel disease
-diabetes
-glaucoma
-heart disease
-high blood pressure
-over active thyroid
-an unusual or allergic reaction to epinephrine, sulfites, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using Adrenalin?

Your conditions will be closely monitored while you are receiving this medicine.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Adyphren II Warnings (Brand)


Epinephrine Professional Warnings (Brand)


Adyphren Amp Warnings (Brand)


Symjepi Warnings (Brand)


What may interact with SYMJEPI?

This medicine is only used during an emergency. Significant drug interactions are not likely during emergency use.

What should I tell my health care provider before I take SYMJEPI?

They need to know if you have any of the following conditions:
-diabetes
-heart disease
-high blood pressure
-lung or breathing disease, like asthma
-Parkinson''s disease
-thyroid disease
-an unusual or allergic reaction to epinephrine, sulfites, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using SYMJEPI?

Keep this medicine ready for use in the case of a severe allergic reaction. Make sure that you have the phone number of your doctor or health care professional and local hospital ready. Remember to check the expiration date of your medicine regularly. You may need to have additional units of this medicine with you at work, school, or other places. Talk to your doctor or health care professional about your need for extra units. Some emergencies may require an additional dose. Check with your doctor or a health care professional before using an extra dose.

After use, go to the nearest hospital or call 911. Avoid physical activity. Make sure the treating health care professional knows you have received an injection of this medicine. You will receive additional instructions on what to do during and after use of this medicine before a medical emergency occurs.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and heat. The solution should be clear in color. If the solution is discolored or contains particles it must be replaced. Throw away any unused medicine after the expiration date. Ask your doctor or pharmacist about proper disposal of the injector if it is expired or has been used. Always replace your auto-injector before it expires.

Auvi-Q Warnings (Brand)


What may interact with Auvi-Q?

This medicine is only used during an emergency. Significant drug interactions are not likely during emergency use.

What should I tell my health care provider before I take Auvi-Q?

They need to know if you have any of the following conditions:
-diabetes
-heart disease
-high blood pressure
-lung or breathing disease, like asthma
-Parkinson''s disease
-thyroid disease
-an unusual or allergic reaction to epinephrine, sulfites, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using Auvi-Q?

Keep this medicine ready for use in the case of a severe allergic reaction. Make sure that you have the phone number of your doctor or health care professional and local hospital ready. Remember to check the expiration date of your medicine regularly. You may need to have additional units of this medicine with you at work, school, or other places. Talk to your doctor or health care professional about your need for extra units. Some emergencies may require an additional dose. Check with your doctor or a health care professional before using an extra dose.

After use, go to the nearest hospital or call 911. Avoid physical activity. Make sure the treating health care professional knows you have received an injection of this medicine. You will receive additional instructions on what to do during and after use of this medicine before a medical emergency occurs.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and heat. The solution should be clear in color. If the solution is discolored or contains particles it must be replaced. Throw away any unused medicine after the expiration date. Ask your doctor or pharmacist about proper disposal of the injector if it is expired or has been used. Always replace your auto-injector before it expires.

EpiPen Warnings (Brand)


What may interact with EpiPen?

This medicine is only used during an emergency. Significant drug interactions are not likely during emergency use.

What should I tell my health care provider before I take EpiPen?

They need to know if you have any of the following conditions:
-diabetes
-heart disease
-high blood pressure
-lung or breathing disease, like asthma
-Parkinson''s disease
-thyroid disease
-an unusual or allergic reaction to epinephrine, sulfites, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using EpiPen?

Keep this medicine ready for use in the case of a severe allergic reaction. Make sure that you have the phone number of your doctor or health care professional and local hospital ready. Remember to check the expiration date of your medicine regularly. You may need to have additional units of this medicine with you at work, school, or other places. Talk to your doctor or health care professional about your need for extra units. Some emergencies may require an additional dose. Check with your doctor or a health care professional before using an extra dose.

After use, go to the nearest hospital or call 911. Avoid physical activity. Make sure the treating health care professional knows you have received an injection of this medicine. You will receive additional instructions on what to do during and after use of this medicine before a medical emergency occurs.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and heat. The solution should be clear in color. If the solution is discolored or contains particles it must be replaced. Throw away any unused medicine after the expiration date. Ask your doctor or pharmacist about proper disposal of the injector if it is expired or has been used. Always replace your auto-injector before it expires.

Adyphren Warnings (Brand)


EPIsnap Warnings (Brand)


neffy Warnings (Brand)


EpinephrineSnap-EMS Warnings (Brand)


epinephrine Pros & Cons (Generic)


Epinephrine Pros and Cons

pros header.svg

  • Epinephrine is a lifesaving drug that can be used for emergency treatment of anaphylaxis. 
  • Epinephrine can be self-injected using a prefilled single-dose automatic injection device.
  • It can be given by intramuscular injection or subcutaneous injection into the thigh, through clothing, if needed.

cons header.svg

  • You have to learn how to inject epinephrine correctly using the pre-filled auto-injector.
  • You must store epinephrine injection at room temperature and prevent exposure to extreme temperatures.
  • This medication can cause heart problems like fast or irregular heart rate.

epinephrine Pharmacist Tips (Generic)


Epinephrine Tips from Pharmacists

  • Ask your doctor or pharmacist if you don’t understand how or when to use the automatic injection device.

  • Always carry two doses of epinephrine injection with you. Call 911 or emergency services after you have injected the medicine.

  • Only inject epinephrine in the middle or outer thigh. Do not inject this medicine into the buttocks, hand, foot, or any other part of the body. You can give the injection through clothing, if necessary.

  • When giving a young child an epinephrine injection, hold their leg still to prevent movement during the treatment.

  • Store epinephrine at room temperature and protect it from light.

epinephrine Rx Savings Tips (Generic)


Epinephrine Rx Savings Tips

Epinephrine is a generic medication and it is available at significantly lower prices than the brand names. Brand name EpiPen Auto-Injector and others and generic epinephrine contain the same medicine and are equally effective and safe. For most medications, generic drugs offer better value. A BuzzRx epinephrine coupon can result in big savings on the brand name and generic epinephrine auto-injector. With a BuzzRx discount card, savings card, or discount coupons, the medication could cost you a fraction of retail prices. Epinephrine may be under $250.50 for two injectors of the 0.3 mg / 0.3 ml dose at Walmart, Walgreens, Rite Aid, CVS Pharmacy, and other participating pharmacies with a BuzzRx discount card or free coupon. For the biggest discounts on epinephrine, give the checkout clerk your BuzzRx epinephrine discount coupon when you drop off your prescriptions at the pharmacy counter.


Lowest Price for Epinephrine
Brand
N/A
Generic
$250.35

VIEW DISCOUNTS
Pricing based on most commonly-filled versions. Select the strength and quantity of your medication for the most accurate pricing.

epinephrine Common Questions (Generic)


Common Questions about Epinephrine


What are 3 uses for epinephrine?

Epinephrine (adrenaline) is used in emergency situations for the treatment of serious hypersensitivity reactions, including anaphylaxis, including reactions caused by insect bites or stings, foods, drugs, or other substances. Intracardiac or parenteral epinephrine may be used during cardiopulmonary resuscitation. This medicine may also be used during severe asthma exacerbations.



What does epinephrine do to the body?

Epinephrine has significant effects on many body tissues. Epinephrine’s effects include rapidly improving breathing, stimulating myocardial contractility (heart muscle contraction), raising blood pressure, and reducing swelling in the throat.



Is epinephrine safe to use?

Epinephrine use is generally safe when used as directed by otherwise healthy individuals. It is a life-saving drug that rarely causes harm, even if it is given when not needed.



How long does epinephrine last?

Epinephrine has a rapid onset of action, but its effects may not last long. It is not a substitute for professional medical treatment. Seek emergency medical care immediately after you receive an epinephrine injection.



Is epinephrine a steroid?

No, epinephrine is not a steroid. It is a naturally occurring hormone made by the adrenal glands in the body. Epinephrine plays a role in the body’s fight-or-flight response during periods of stress.



Can epinephrine be used during pregnancy?

Epinephrine may be used during pregnancy. This drug should be used with caution if maternal blood pressure is high.



What is the price of epinephrine without insurance?

Without insurance, epinephrine can be as high as $540.99, but with a free BuzzRx prescription discount coupon, you could pay as low as $250.35 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not.



What is the price of epinephrine with insurance?

Ask your pharmacist or insurance provider for your copay price on epinephrine—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins.

You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for epinephrine. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.