Estradiol

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jul 06, 2022

Pros & Cons


What are the pros and cons of estradiol?

pros header.svg

  • Estradiol is available as an oral tablet, which is easier to use than a vaginal cream, topical gel, or ring.
  • It is available as a low-cost generic drug.
  • The tablets come in various strengths, so it’s easy to customize the dose.
  • Estradiol helps to prevent bone loss and weak bones after menopause.

cons header.svg

  • It can be challenging to keep track of cyclic estradiol administration (for example, 3 weeks off, 1 week on).
  • Estradiol can increase your risk of certain types of cancers and cardiovascular disease.
  • It can worsen certain health conditions like diabetes and asthma.
  • There are other, safer treatments available to prevent osteoporosis (bone loss).