Do not take this medication with any of the following medicines:

-cidofovir
-ketorolac
This medicine may interact with the following medications:

-alcohol
-antihistamines for allergy, cough and cold
-antiviral medicines for HIV or AIDS
-aspirin and aspirin-like medicines
-atropine
-certain antibiotics like clarithromycin, erythromycin
-certain medicines for anxiety or sleep
-certain medicines for depression like amitriptyline, fluoxetine, lithium, sertraline
-certain medicines for fungal infection like ketoconazole and itraconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, primidone
-certain medicines for stomach problems like dicyclomine, hyoscyamine
-certain medicines for travel sickness like scopolamine
-certain medicines that treat or prevent blood clots like warfarin, enoxaparin, dalteparin, apixaban, dabigatran, and rivaroxaban
-diuretics
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-ipratropium
-local anesthetics like lidocaine, pramoxine, tetracaine
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-medicines that relax muscles for surgery
-methotrexate
-other narcotic medicines for pain or cough
-other NSAIDS, medicines for pain and inflammation, like naproxen
-pemetrexed
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-rifampin
-steroid medicines like prednisone or cortisone

They need to know if you have any of these conditions:

-bleeding disorder
-brain tumor
-constipation
-coronary artery bypass graft (CABG) within the past 2 weeks
-dehydration
-depression
-diarrhea
-drug abuse or addiction
-head injury
-heart attack
-heart disease
-heart failure
-high blood pressure
-if you often drink alcohol
-kidney disease
-liver disease
-low adrenal gland function
-lung disease, asthma, or breathing problem
-receiving steroids like dexamethasone or prednisone
-seizures
-smoke tobacco cigarettes
-stomach bleeding
-stomach ulcers, other stomach or intestine problems
-stroke
-take drugs that treat or prevent blood clots
-taken an MAOI like Marplan, Nardil, or Parnate in the last 14 days
-vomiting
-an unusual or allergic reaction to ibuprofen, hydrocodone, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your health care provider if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to this medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take this medicine for a long time.
Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a medicine for a nonmedical reason. If you have pain, you have a medical reason to take pain medicine. Your health care provider will tell you how much medicine to take. If your health care provider wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.
If you take other medicines that also cause drowsiness like other narcotic pain medicines, benzodiazepines, or other medicines for sleep, you may have more side effects. Give your health care provider a list of all medicines you use. He or she will tell you how much medicine to take. Do not take more medicine than directed. Get emergency help right away if you have trouble breathing or are unusually tired or sleepy.
Talk to your health care provider about naloxone and how to get it. Naloxone is an emergency medicine used for an opioid overdose. An overdose can happen if you take too much opioid. It can also happen if an opioid is taken with some other medicines or substances, like alcohol. Know the symptoms of an overdose, like trouble breathing, unusually tired or sleepy, or not being able to respond or wake up. Make sure to tell caregivers and close contacts where it is stored. Make sure they know how to use it. After naloxone is given, you must get emergency help right away. Naloxone is a temporary treatment. Repeat doses may be needed.
This medicine will cause constipation. If you do not have a bowel movement for 3 days, call your health care provider.
Check with your health care provider if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medicine.
Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many non-prescription medicines contain aspirin, ibuprofen, or naproxen. Always read labels carefully.
This medicine can cause serious ulcers and bleeding in the stomach. It can happen with no warning. Smoking, drinking alcohol, older age, and poor health can also increase risks. Call your health care provider right away if you have stomach pain or blood in your vomit or stool.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Talk to your health care provider if you are pregnant before taking this medicine. Taking this medicine between weeks 20 and 30 of pregnancy may harm your unborn baby. Your health care provider will monitor you closely if you need to take it. After 30 weeks of pregnancy, do not take this medicine.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effects of this medicine. Avoid alcoholic drinks.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your health care provider if the problem does not go away or is severe.

Keep out of the reach of children and pets. This drug can be abused. Keep it in a safe place to protect it from theft. Do not share it with anyone. It is only for you. Selling or giving away this drug is dangerous and against the law.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Talk to your health care provider about how to dispose of unused drug. Special directions may apply.
This medicine may cause harm and death if it is taken by other adults, children, or pets. Return medicine that has not been used to an official disposal site. Contact the DEA at 1-800-882-9539 or your city/county government to find a site. If you cannot return the medicine, flush it down the toilet. Do not use the medicine after the expiration date.