Oxycodone

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Oct 19, 2022

Side Effects


Oxycodone Side Effects

Possible side effects of oxycodone are listed below. Tell your doctor if these side effects are severe or do not go away in a few days.

  • Drowsiness
  • Dry mouth
  • Stomachache
  • Headache
  • Flushing
  • Mood changes

Less commonly, oxycodone can cause serious side effects. Seek immediate medical help if you have the following symptoms:

  • Fever, sweating, shivering, confusion, agitation, hallucinations, fast heartbeat, nausea, vomiting, diarrhea, muscle stiffness, muscle twitching, loss of coordination
  • Weakness, dizziness, nausea, vomiting, loss of appetite
  • Erectile dysfunction (inability to achieve or keep an erection)
  • Menstrual irregularities
  • Decreased libido (sexual desire)
  • Swelling of the throat, tongue, lips, eyes, face, hands, lower legs, ankles, or feet
  • Skin rash, hives, itching
  • Chest pain
  • Difficulty breathing or swallowing
  • Respiratory depression (slowed breathing)
  • Extreme drowsiness
  • Seizures
  • Lightheadedness with changes in position

The above list may not include all the potential adverse effects of oxycodone. Contact your doctor if the side effects are unusual or severe or they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Lisinopril Overdose: In case of an accidental or intentional overdose of oxycodone, contact your doctor immediately. You can also call the national poison control center at 1-800-222-1222. If a person cannot be awakened, has trouble breathing, has collapsed, or has had a seizure, call 911. 

Symptoms of an oxycodone overdose may include difficulty breathing, slowed or stopped breathing, narrowing or widening of the pupils, extreme sleepiness, limp muscles, cold and clammy skin, and unresponsiveness.

Talk to your doctor about taking a rescue medication called naloxone should an overdose occur. Naloxone can reverse the life-threatening effects of an opioid overdose. Make sure you and others in your household know how to recognize an overdose and use naloxone and what to do until emergency medical services arrive.

Source: FDA