Do not take this medication with any of the following:
-Cisapride
-Dronedarone
-Metoclopramide
-Pimozide
-Thioridazine
This medication may also interact with the following:
-Alcohol
-Antihistamines for allergy, cough, and cold
-Carbamazepine
-Certain medications for anxiety or sleep
-Certain medications for depression like amitriptyline, fluoxetine, paroxetine, sertraline
-Certain medications for fungal infections like fluconazole, posaconazole
-General anesthetics like halothane, isoflurane, methoxyflurane, propofol
-Levodopa or other medications for Parkinson's disease
-Medications for blood pressure
-Medications for seizures
-Medications that relax muscles for surgery
-Narcotic medications for pain
-Other medications that prolong the QT interval (cause an abnormal heart rhythm)
-Phenothiazines like chlorpromazine, prochlorperazine

They need to know if you have any of these conditions:
-Dementia
-Diabetes
-Difficulty swallowing
-Have trouble controlling your muscles
-Heart disease
-High cholesterol
-History of breast cancer
-History of irregular heartbeat
-History of stroke
-Kidney disease
-Liver disease
-Low blood counts, like low white cell, platelet, or red cell counts
-Low blood pressure
-Parkinson's disease
-Seizures
-Stomach or intestinal problems
-An unusual or allergic reaction to paliperidone, risperidone, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Tell your care team if symptoms do not start to get better or if they get worse. Do not stop taking except on your care team's advice. You may develop a severe reaction. Your care team will tell you how much medication to take.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks.
This medication can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your care team right away.
This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.
The tablet shell for some brands of this medication does not dissolve. This is normal. The tablet shell may appear whole in the stool. This is not a cause for concern.

Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medication after the expiration date.