Sertraline

( Zoloft )

Last Reviewed: Jan 14, 2025

Pharmacist Tips


Sertraline (Zoloft) Tips from Pharmacists

  • You can take sertraline without regard to meals, but if it causes stomach upset, taking it with food might help.

  • Dilute sertraline liquid concentrate in 4 ounces (120 mL) of water or lemon drinks. Drink the mixture immediately.

  • Sertraline can make you feel dizzy, drowsy, and tired. Do not drive or do other hazardous activities until you know how it affects you.

  • Tell your doctor if you develop sexual side effects on sertraline. Your healthcare provider may adjust your dose.

  • Avoid drinking alcohol while on sertraline. Alcohol can make side effects like drowsiness and dizziness worse.

  • Do not suddenly stop taking sertraline. This can lead to antidepressant discontinuation syndrome and withdrawal symptoms.

  • Seek immediate medical care for any unusual changes in mood or behavior or suicidal thoughts or behavior after starting sertraline. 

  • Tell lab personnel you are on sertraline before any laboratory tests. Sertraline can interfere with the results of some urine drug screens.