Warnings


What may interact with TOLSURA?

Do not take this medicine with any of the following medications:

-alfuzosin
-alprazolam
-avanafil
-certain medicines for blood pressure like felodipine, nisoldipine
-certain medicines for cholesterol like cerivastatin, lovastatin, simvastatin, lomitapide
-certain medicines for the heart like disopyramide, dofetilide, dronedarone, eplerenone, ivabradine, quinidine, ranolazine
-cisapride
-colchicine (if you have liver or kidney problems)
-conivaptan
-ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
-irinotecan
-isavuconazole
-lurasidone
-methadone
-midazolam
-naloxegol
-nevirapine
-other medicines that prolong the QT interval (cause an abnormal heart rhythm)
-pimozide
-red yeast rice
-sirolimus
-thioridazine
-ticagrelor
-triazolam

This medicine may also interact with the following medications:

-aliskiren
-amlodipine
-antacids
-antiviral medicines for HIV or AIDS
-aprepitant
-atorvastatin
-buprenorphine
-certain antibiotics like ciprofloxacin, clarithromycin, erythromycin
-certain medicines for bladder problems like fesoterodine, solifenacin, tolterodine
-certain medicines for cancer like axitinib, bortezomib, busulfan, dabrafenib, dasatinib, docetaxel, erlotinib, gefitinib, ibrutinib, imatinib, ixabepilone, lapatinib, nilotinib, ponatinib, sunitinib, trabectedin, trimetrexate, vinca alkaloids
-certain medicines for depression, anxiety, or psychotic disturbances like aripiprazole, buspirone, diazepam, haloperidol, perospirone, quetiapine, risperidone
-certain medicines for erectile dysfunction like vardenafil, sildenafil, tadalafil
-certain medicines for pain like alfentanil, fentanyl, oxycodone, sufentanil
-certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
-certain medicines that treat or prevent blood clots like warfarin, dabigatran, rivaroxaban
-certain medicines for seizures like carbamazepine, phenytoin
-certain medicines for tuberculosis like isoniazid, INH, rifabutin, rifampin, rifapentine
-cilostazol
-cinacalcet
-cyclosporine
-digoxin
-eletriptan
-everolimus
-halofantrine
-isradipine
-meloxicam
-nadolol
-nifedipine
-other medicines for fungal infections
-praziquantel
-ramelteon
-repaglinide
-salmeterol
-saxagliptin
-steroid medicines like budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone
-tacrolimus
-tamsulosin
-tolvaptan
-verapamil
-ziprasidone

What should I tell my health care provider before I take TOLSURA?

They need to know if you have any of these conditions:

-heart disease
-history of irregular heartbeat
-immune system problems
-kidney disease
-liver disease
-lung or breathing disease
-an unusual or allergic reaction to itraconazole, or other antifungal medicines, foods, dyes or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using TOLSURA?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how the medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.