What side effects may I notice from receiving Vagifem?

Side effects that you should report to your care team as soon as possible:
-Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
-Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
-Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
-Change in vision
-Gallbladder problems—severe stomach pain, nausea, vomiting, fever
-Increase in blood pressure
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
-Unusual vaginal discharge, itching, or odor
-Vaginal bleeding after menopause, pelvic pain
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Bloating
-Breast pain or tenderness
-Hair loss
-Nausea
-Stomach pain
-Swelling of the ankles, hands, or feet
-Vaginal irritation at application site

This list may not describe all possible side effects for Vagifem. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.