Zoloft

Medically Reviewed by HaVy Ngo, Pharm.D.

Last Reviewed: Jun 06, 2022

Common Questions


Common Questions about Zoloft (sertraline)


Is Zoloft an SSRI?

Yes, Zoloft is an SSRI (selective serotonin reuptake inhibitor). SSRIs are a class of antidepressant medications used to treat depression and anxiety disorders.



Is Zoloft a controlled substance?

The active ingredient in Zoloft is sertraline, which is NOT a controlled substance.



How long does Zoloft take to work?

On average, it takes Zoloft 2-6 weeks to start working. It can take up to 12 weeks for Zoloft to have its full effect. This is not a medicine that works from the first day. It will be several weeks before you notice a difference in your symptoms.



Does Zoloft cause weight gain?

Like other SSRIs and antidepressants, sertraline (Zoloft) can cause weight gain. This side effect occurs in around 25% of people and usually develops after prolonged use (six months or more of Zoloft use). However, the medicine can also have the opposite effect, i.e., some patients may lose weight on Zoloft.



How does Zoloft make you feel?

After several weeks of use, once Zoloft has had a chance to kick in, it can make you less anxious and less fearful. In people with obsessive compulsive disorder (OCD), Zoloft may reduce the urge to perform tasks repetitively. Zoloft can also improve panic attacks, sleep, and energy levels and restore interest in previously enjoyed activities. 



Are Zoloft and Xanax the same thing?

No, Zoloft and Xanax are different medications. Zoloft is an SSRI antidepressant. Xanax is a benzodiazepine that is used for the short-term treatment of anxiety. Xanax has the potential for abuse and addiction.



Can you drink alcohol on Zoloft?

Both Zoloft and alcohol have effects on the brain. The U.S. Food and Drug Administration (FDA) advises against drinking alcohol while on Zoloft. Drinking alcohol while on Zoloft can increase side effects such as dizziness, drowsiness, and difficulty concentrating.



What time of day should you take Zoloft?

You can take Zoloft either in the morning or the evening. If Zoloft makes you drowsy or dizzy, it may be better to take it at bedtime. Be consistent and take Zoloft at around the same time every day. This helps you remember to take your medicine and helps maintain constant drug levels in your body.



Does Zoloft keep you awake at night?

Zoloft can cause sleep difficulties in some people, including falling asleep and staying asleep. If you experience these side effects of Zoloft, it may help to take your medicine in the morning.



Is 25 mg of Zoloft enough for depression?

The usual starting dose of Zoloft is 25 mg or 50 mg daily. Your doctor may increase the dose of Zoloft at weekly intervals based on your response to the medication. The maximum Zoloft dose in adults is 200 mg daily.



If the Medicare prescription drug plan covers Zoloft, how much do you pay?

After eligible patients have satisfied their deductible, they enter the post-deductible stage where the patient pays the copay and the health insurance plan pays the rest of the cost of the drug.



What dosages are available for Zoloft?

Zoloft is available in the following strengths: 25mg, 50mg, 100mg. This drug is available in the following forms: tablet and ampule. Make sure to follow your prescription regimen according to your doctor’s instructions.



What is the price of Zoloft without insurance?

Without insurance, Zoloft can be as high as $82.82 (generic), but with a free BuzzRx prescription discount coupon, you could pay as low as $10.24 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. 



What is the price of Zoloft with insurance?

Ask your pharmacist or insurance provider for your copay price on Zoloft—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins.

You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for Zoloft . When using the BuzzRx lookup tool to find the price of your medication, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.