What is clopidogrel (Plavix) used for?

Clopidogrel is used to treat acute coronary syndrome, i.e., myocardial infarction (heart attack) or unstable angina (severe chest pain due to heart problems). It is also used to prevent future heart attacks and stroke in people who have already had these events or are at high risk of cardiovascular disease (conditions involving the heart and/or blood vessels). Clopidogrel is also given to patients with peripheral arterial disease (also called peripheral vascular disease), a condition in which there is a hardening or narrowing of the arteries in the legs, leading to poor circulation.

There may be other uses of clopidogrel (Plavix generic) - your doctor or pharmacist can give you further drug information.

How does clopidogrel (Plavix) work?

Platelets are blood cells that play an important role in coagulation (stopping bleeding) by forming blood clots. Clopidogrel prevents platelet aggregation, meaning it stops platelets from sticking together or clumping together and forming harmful clots. Blood clots can block the arteries that supply blood to the heart and brain, leading to heart attack or stroke. Taking clopidogrel helps to prevent blood clots and keep blood flowing smoothly. An enzyme called cytochrome P450 that is present in the human body is essential for the conversion of clopidogrel to its active metabolite (active form).  

What is the dosage of clopidogrel (Plavix)?

For acute coronary syndrome, the usual oral dose of clopidogrel is a single 300-mg loading dose, followed by clopidogrel 75 mg once a day. In patients with recent myocardial infarction (heart attack), recent stroke, or established peripheral arterial disease, clopidogrel is given at a dose of 75 mg daily without an initial loading dose