Ezetimibe

( Zetia )

Medically Reviewed by HaVy Ngo, Pharm.D.

Last Reviewed: Jun 07, 2022

Pros & Cons


What are the pros and cons of ezetimibe (Zetia)?

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  • Available as a generic at a lower price
  • Ezetimibe can be taken with or without food.
  • Once-daily dosing and being available as combination pills with atorvastatin are excellent for compliance.
  • Effective at lowering LDL (the bad cholesterol) by itself or in combination with other medications in people who cannot do this through diet and exercise.


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  • Does not increase HDL (the “good” cholesterol) as well as other medications
  • Does not lower triglycerides (another type of “bad” fat) as well as other medications 
  • Ezetimibe is not proven to lower the risk of cardiovascular events such as heart attacks, stroke, and other heart diseases.
  • Does not lower cholesterol as well as statin as monotherapy (being used alone)
  • Not enough data on pregnant and breastfeeding women