Do not take this medicine with any of the following medications:

-alfuzosin
-certain medicines for anxiety or sleep like midazolam, triazolam
-certain medicines for cancer like apalutamide, enzalutamide
-certain medicines for cholesterol like lomitapide, lovastatin, simvastatin
-certain medicines for fungal infections like fluconazole, posaconazole
-certain medicines for hepatitis C like elbasvir; grazoprevir, boceprevir, dasabuvir; ombitasvir; paritaprevir; ritonavir
-cisapride
-dronedarone
-eletriptan
-ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
-lurasidone
-meperidine
-naloxegol
-pimozide
-ranolazine
-red yeast rice
-ribociclib
-rifampin
-silodosin
-St. John''s wort
-thioridazine
-ubrogepant

This medicine may also interact with the following medications:

-atovaquone
-bedaquiline
-birth control pills
-bosentan
-bupropion
-certain medicines for blood pressure like felodipine, nicardipine, nifedipine
-certain medicines for cancer like abemaciclib, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine
-certain medicines for cholesterol like atorvastatin
-certain medicines for erectile dysfunction like sildenafil, tadalafil, vardenafil
-certain medicines for fungal infections like isavuconazonium, itraconazole, ketoconazole, voriconazole
-certain medicines for irregular heartbeat like amiodarone, bepridil, lidocaine, quinidine
-certain medicines for seizures like carbamazepine, lamotrigine, phenobarbital, phenytoin, valproate
-certain medicines that treat or prevent blood clots like rivaroxaban, warfarin
-clarithromycin
-colchicine
-cyclosporine
-disulfiram
-elagolix
-fentanyl
-fostamatinib
-methadone
-metronidazole
-other medicines for HIV or AIDS
-other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone
-quetiapine
-rifabutin
-rifapentine
-salmeterol
-sirolimus
-steroid medicines like budesonide, dexamethasone, fluticasone, prednisone, triamcinolone
-tacrolimus
-trazodone

They need to know if you have any of these conditions:

-diabetes
-heart disease
-hemophilia
-history of pancreatitis
-liver disease
-an unusual or allergic reaction to lopinavir, ritonavir, other medicines, castor oil, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or healthcare provider for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.

This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

Some products may contain alcohol. Ask your pharmacist or healthcare provider if this medicine contains alcohol. Be sure to tell all healthcare providers you are taking this medicine. Certain medicines, like metronidazole and disulfiram, can cause an unpleasant reaction when taken with alcohol. The reaction includes flushing, headache, nausea, vomiting, sweating, and increased thirst. The reaction can last from 30 minutes to several hours.

Keep out of the reach of children.

Store in the refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Throw away any unused medicine after the expiration date. If stored at room temperature, up to 25 degrees C (77 degrees F), you must throw the medicine away after 2 months.