Do not take this medicine with any of the following medications:

-cabotegravir
-cabotegravir; rilpivirine
-dasabuvir; ombitasvir; paritaprevir; ritonavir
-delavirdine
-idelalisib
-lonafarnib
-ombitasvir; paritaprevir; ritonavir
-ranolazine
-voriconazole
This medicine may also interact with the following medications:

-azithromycin
-certain antivirals for HIV
-certain medicines for fungal infections like fluconazole, ketoconazole, itraconazole, or posaconazole
-clarithromycin
-dapsone
-ethambutol
-female hormones, like estrogen or progestins and birth control pills
-isoniazid
-sulfamethoxazole; trimethoprim

They need to know if you have any of these conditions:

-kidney disease
-tuberculosis (TB) infection
-wear contact lenses
-an unusual or allergic reaction to rifabutin, rifamycins, other medicines, foods, dyes or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your health care provider if your symptoms do not start to get better or if they get worse.
Do not treat diarrhea with over the counter products. Contact your health care provider if you have diarrhea that lasts more than 2 days or if it is severe and watery.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Birth control may not work properly while you are taking this medicine. Talk to your health care provider about using an extra method of birth control.
This medicine can color your teeth, urine, sweat, tears, and mucous. The color may stain your teeth for good. The color in tears may also stain soft contact lenses for good. If you wear contact lenses, ask your health care provider when you can use your lenses again.

Keep out of the reach of children and pets.
Store at 25 degrees C (77 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, take the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.