Do not take this medication with any of the following:
-MAOIs, such as Marplan, Nardil, and Parnate
This medication may also interact with the following:
-Alcohol
-Antihistamines for allergy, cough, and cold
-Certain medications for anxiety or sleep
-Certain medications for depression, such as amitriptyline, fluoxetine, sertraline
-Certain medications for seizures, such as phenobarbital, primidone
-Dobutamine
-Dopamine
-Epinephrine
-General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol
-Isoproterenol
-Medications that relax muscles for surgery
-Norepinephrine
-Opioid medications for pain
-Phenothiazine, such as chlorpromazine, mesoridazine, prochlorperazine, thioridazine

They need to know if you have any of these conditions:
-Frequently drink alcohol
-Kidney disease
-Liver disease
-Low blood pressure
-Narcolepsy
-Schizophrenia
-Sleep apnea
-An unusual or allergic reaction to opicapone, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
Do not suddenly stop taking this medication. You may develop a severe reaction. Your care team will tell you how much medication to take. If your care team wants you to stop this medication, the dose may be slowly lowered over time to avoid any side effects.
This medication may affect your coordination, reaction time, or judgement. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
When taking this medication, you may fall asleep without notice. You may be doing activities, such as driving a car, talking, or eating. You may not feel drowsy before it happens. Contact your care team right away if this happens to you.
There have been reports of increased sexual urges or other strong urges, such as gambling while taking this medication. If you experience any of these while taking this medication, you should report this to your care team as soon as possible.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

Keep out of the reach of children and pets.
Store at room temperature below 30 degrees C (86 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.