Do not take this medicine with any of the following medications:

-alfuzosin
-certain medicines for blood pressure, heart disease, irregular heart beat such as dronedarone, ivabradine, ranolazine
-cisapride
-colchicine (if you have liver or kidney problems)
-elbasvir; grazoprevir
-lurasidone
-medicines for cholesterol such as lomitapide, lovastatin, simvastatin
-medicines for headaches such as dihydroergotamine, ergonovine, ergotamine, methylergonovine
-midazolam
-naloxegol
-pimozide
-red yeast rice
-rifampin
-sildenafil (for the treatment of pulmonary arterial hypertension)
-St. John''s Wort
-triazolam
This medicine may also interact with the following medications:

-artemether; lumefantrine
-bosentan
-certain antibiotics such as clarithromycin, rifabutin, rifapentine
-certain other antiviral medicines for HIV such as didanosine, indinavir, maraviroc, saquinavir, or lopinavir; ritonavir
-certain medicines for anxiety or sleep such as buspirone, diazepam, estazolam, zolpidem
-certain medicines for blood pressure and heart disease such as amlodipine, carvedilol, diltiazem, felodipine, metoprolol, nicardipine, nifedipine, timolol, verapamil
-certain medicines for cancer such as dasatinib, nilotinib, vinblastine, vincristine
-certain medicines for depression such as amitriptyline, desipramine, imipramine, nortriptyline, paroxetine, sertraline, and trazodone
-certain medicines for erectile dysfunction such as avanafil, sildenafil, tadalafil, vardenafil
-certain medicines for fungal infection such as itraconazole, ketoconazole, posaconazole, voriconazole
-certain medicines for hepatitis infection such as boceprevir, simeprevir
-certain medicines for psychotic disturbances such as quetiapine, risperidone, thioridazine
-certain medicines for seizures such as carbamazepine, phenobarbital, phenytoin
-certain medicines that treat or prevent blood clots such as apixaban, rivaroxaban, warfarin
-clopidogrel
-female hormones such as estrogens and progestins and birth control pills
-medicines for cholesterol such as atorvastatin, pravastatin, rosuvastatin
-medicines for irregular heart beat such as amiodarone, bepridil, digoxin, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine
-medicines that lower your chance of fighting infection such as cyclosporine, everolimus, sirolimus, tacrolimus
-narcotic medicines for pain such as buprenorphine, buprenorphine; naloxone, methadone
-omeprazole
-salmeterol
-steroid medicines such as betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, prednisolone, triamcinolone
-ticagrelor

They need to know if you have any of these conditions:

-diabetes
-hemophilia
-liver disease
-an unusual or allergic reaction to darunavir, sulfa medicines, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or healthcare provider for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.
Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.