What side effects may I notice from receiving Rebif?

Side effects that you should report to your doctor or health care professional as soon as possible:

-a skin sore with a black-blue color, swelling, or drainage
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-depression
-seizures
-severe stomach pain
-signs and symptoms of infection like fever or chills,cough, sore throat, pain or difficulty passing urine
-swelling of the ankles
-unusual bleeding or bruising
-unusually weak or tired
-yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-dizziness
-headache
-menstrual changes
-muscle aches
-nausea
-pain, redness, or irritation at site where injected
-tiredness

This list may not describe all possible side effects for Rebif. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.