Do not take this medicine with any of the following medications:
-ketorolac
-probenecid

This medicine may also interact with the following medications:
-acetazolamide
-alcohol
-aspirin and aspirin-like drugs
-bismuth subsalicylate
-cidofovir
-diuretics
-flavocoxid
-lithium
-medicines that treat or prevent blood clots like clopidel, ticlopidine, warfarin
-medicines for blood pressure
-methazolamide
-methotrexate
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-sulfinpyrazone
-varicella virus live vaccine

They need to know if you have any of these conditions:

-asthma
-drink more than 3 alcohol-containing drinks a day
-heart disease
-high blood pressure
-kidney disease
-liver disease
-stomach bleeding or ulcers
-an unusual or allergic reaction to salsalate, other salicylates, aspirin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or health care provider if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.
This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care provider.
Do not take medicines such as aspirin, ibuprofen, and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.
This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and can cause death.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Talk to your health care provider if you are pregnant before taking this medicine. Taking this medicine between weeks 20 and 30 of pregnancy may harm your unborn baby. Your health care provider will monitor you closely if you need to take it. After 30 weeks of pregnancy, do not take this medicine.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed.
Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.