Do not take this medicine with any of the following medications:

-cisapride
-dofetilide
-dronedarone
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-pimozide
-thioridazine
-ziprasidone
This medicine may also interact with the following medications:

-aclidinium
-antihistamines for allergy
-antiviral medicines for HIV or AIDS
-atropine
-beta-blockers like metoprolol and propranolol
-certain antibiotics like clarithromycin and telithromycin
-certain medicines for bladder problems like oxybutynin, tolterodine
-certain medicines for depression, anxiety, or psychotic disturbances
-certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole, voriconazole
-certain medicines for Parkinson''s disease like benztropine, trihexyphenidyl
-certain medicines for stomach problems like dicyclomine, hyoscyamine
-certain medicines for travel sickness like scopolamine
-conivaptan
-diuretics
-ipratropium
-medicines for colds
-other medicines for breathing problems
-other medicines that prolong the QT interval (cause an abnormal heart rhythm)
-nefazodone
-tiotropium

They need to know if you have any of these conditions:

-bone problems
-diabetes
-eye disease, vision problems
-heart disease
-high blood pressure
-history of irregular heartbeat
-immune system problems
-infection
-kidney disease
-pheochromocytoma
-prostate disease
-seizures
-thyroid disease
-trouble passing urine
-an unusual or allergic reaction to fluticasone, umeclidinium, vilanterol, lactose, milk proteins, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular checkups. Tell your doctor or health care professional if your symptoms do not get better. Do not use this medicine more than once every 24 hours.
NEVER use this medicine for an acute asthma or COPD attack. You should use your short-acting rescue inhalers for this purpose. If your symptoms get worse or if you need your short-acting inhalers more often, call your doctor right away.
If you are going to have surgery tell your doctor or health care professional that you are using this medicine. Try not to come in contact with people with the chicken pox or measles. If you do, call your doctor.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep inhaler away from extreme heat, cold or humidity. Throw away 6 weeks after removing it from the foil pouch, when the dose counter reads "0" or after the expiration date, whichever is first.