Alendronate Sodium

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Sep 07, 2023

Pros & Cons


Alendronate Pros and Cons

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  • Alendronate is an effective treatment for osteoporosis in both men and women. 
  • It is available as once-weekly dosing for convenience.
  • A lower-cost generic version (Fosamax generic) can result in cost savings.
  • The bone-strengthening effects may continue for several years after you stop taking alendronate.

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  • You need to take alendronate first thing in the morning on an empty stomach.
  • You must stay upright and not eat anything for at least 30 minutes after you take a dose.
  • Alendronate can cause esophageal and stomach irritation.
  • It can also cause serious adverse effects, such as osteonecrosis of the jaw and severe pain in the muscles, joints, and bones.