Glimepiride

( Amaryl )

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jul 10, 2023

Common Questions


Common Questions about Glimepiride (Amaryl) 


What is the best time to take glimepiride?

The best time to take glimepiride is with breakfast or your first big meal of the day. Do not take this medicine on an empty stomach. If you skip breakfast, take glimepiride with your first main meal.



Is glimepiride the same as metformin?

No, glimepiride is not the same as metformin, although both are oral anti-diabetes medications. Glimepiride is a sulfonylurea drug that works by stimulating insulin production in the pancreas. Metformin is a biguanide drug that decreases glucose formation in the liver and increases insulin sensitivity.



Can I take glimepiride and metformin together?

Yes, you can take glimepiride and metformin together if your doctor prescribes them. The combination is not only safe but also very effective in the management of type 2 diabetes mellitus.



Who should not take glimepiride?

People who have had allergic reactions to glimepiride in the past should not take this medication. This drug is not for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis. Glimepiride may not be right for people with certain medication conditions such as G6PD deficiency, heart disease, liver or kidney disease.



Does glimepiride lower blood sugar immediately?

The maximum glucose-lowering effect of glimepiride occurs 2-3 hours after taking a dose. The effects of the medicine last for approximately 24 hours.



What is the price of glimepiride without insurance?

Without insurance, glimepiride can be as high as $115.99, but with a free BuzzRx prescription discount coupon, you could pay as low as $12.49 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not.



What is the price of glimepiride with insurance?

Ask your pharmacist or insurance provider for your copay price on glimepiride—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins.

You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for glimepiride. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.