Glimepiride

( Amaryl )

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jul 10, 2023

Pros & Cons


Glimepiride (Amaryl) Pros and Cons

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  • Glimepiride is an oral medication to take by mouth, which is easier than taking insulin injections.
  • You only need to take glimepiride once a day.
  • It is effective in improving glycemic control and lowering HbA1c levels.
  • This medication is available in a lower-cost generic form.
  • Glimepiride is covered by most insurance plans.

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  • Taking glimepiride can put you at risk of hypoglycemia (low blood sugar), especially if you have hepatic or renal impairment (liver or kidney disease). 
  • It may not be the best choice for people over 65 years of age.
  • The effects of glimepiride can lessen over time.
  • It cannot be used to treat type 1 diabetes mellitus or diabetic ketoacidosis.