Progesterone

Medically Reviewed by HaVy Ngo-Hamilton, Pharm.D.

Last Reviewed: Jun 10, 2022

Drug Details


promeGeneric Name:

Progesterone

Common Brands:

Prometrium; First Progesterone MC10; Menopause Formula Progesterone

Availability:

Prescription only

Therapeutic Class:

Progestins; hormone therapy; hormone replacement therapy; progesterone therapy

Forms:

Progesterone intrauterine insert (Progesterone(R) was discontinued on 06/01/2001.

  • Generic progesterone:
    Oral micronized progesterone capsule: 100 mg; 200 mg
  • Crinone: 
    Progesterone vaginal gel/jelly : 4%; 8%
  • Endometrin: 
    Vaginal tablet: 100 mg
  • Prometrium:
    Oral capsule: 100 mg; 200 mg

This medication guide will focus on the generic progesterone oral capsule information.

Administration:

Oral, Intramuscular, Vaginal


Therapeutic Uses:

  • The injection form of progesterone can help stop abnormal uterine bleeding unrelated to menstrual cycle
  • Lack of menstrual periods in women who have not yet reached menopause
  • The capsule form can help prevent overgrowth of the uterus lining in postmenopausal women on estrogen hormone replacement therapy (HRT) Adjunct therapy in assisted reproductive therapy (ART) in female infertility

Controlled Status:

Not a controlled substance


What is progesterone? (Prometrium)?

Natural progesterone is a female hormone; it is a natural hormone. Progesterone plays an important role in regulating ovulation and menstruation. The ovaries produce progesterone in large amounts; the adrenal glands produce smaller amounts of progesterone in both males and females.  

Irregular or absent periods can be signs of low testosterone levels or poorly functioning ovaries.

Progesterone supplementation is a steroid hormone belonging to a class of hormones called progestogens; these synthetic steroid hormones with properties similar to progesterone are medications called progestins. 

Progestins were formulated to mimic the actions of progesterone and bind to progesterone receptors in the body; thus, producing similar effects.

Who can take progesterone? (Prometrium)?

  • Menopausal women who have not had a hysterectomy and are taking conjugated estrogens as menopausal hormone therapy.
  • Women of childbearing age who do not have menstrual periods due to low progesterone levels.
  • Not for use in pregnant women
  • Not for use in children