-Certain antivirals for HIV or hepatitis
-Certain medications for fungal infections, such as ketoconazole, itraconazole, posaconazole, voriconazole
-Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
-Clarithromycin
-Grapefruit and grapefruit juice
-Live virus vaccines
-Medications that lower your chance of fighting infection, such as abatacept, adalimumab, azathioprine, cyclosporine, etanercept, infliximab, rituximab
-Rifampin
-Supplements, such as St. John's wort
Other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

They need to know if you have any of these conditions:
-Cancer
-Current or past tobacco use
-Diabetes
-Have had a heart attack or stroke
-Have had blood clots
-Have been in close contact with someone who has tuberculosis (TB)
-Heart disease
-High blood pressure
-High cholesterol
-HIV or AIDS
-Infection or have had an infection that does not go away, such as tuberculosis (TB), shingles, hepatitis, herpes
-Kidney disease
-Live or have traveled to the Southwest US or the Ohio or Mississippi River valleys
-Liver disease
-Low blood cell levels (white cells, red cells, and platelets)
-Lung or breathing disease, such as asthma or COPD
-Recent or upcoming vaccine
-Stomach or intestine problems
-Taking NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
-Taking steroid medications, such as prednisone or cortisone
-Weakened immune system
-An unusual or allergic reaction to upadacitinib, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
You may need blood work done while you are taking this medication.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
Your care team will screen you for tuberculosis (TB) before you start this medication. If they think you are at risk, you may be treated with medication for TB. You should start taking the medication for TB before you start this medication. Make sure to finish the full course of TB medication.
Talk to your care team about your vaccination history. To lower your risk of infection, you may need certain vaccines before you start this medication.
Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancer if you take this medication. Tobacco use may increase your risk of cancer. Talk to your care team about having your skin checked for cancer while taking this medication. Limit the amount of time you spend in the sun. Wear protective clothing and sunscreen when you are in the sun. Do not use sun lamps, tanning beds, or tanning booths.
This medication may increase the risk of blood clots, heart attack, stroke, or death. High blood pressure, high cholesterol, diabetes, increased age, excess weight, and tobacco use increase this risk. Call emergency services right away if you have symptoms of a heart attack or stroke.
This medication can increase bad cholesterol and fats (such as LDL, triglycerides) and decrease good cholesterol (HDL) in your blood. You may need blood tests to check your cholesterol. Ask your care team what you can do to lower your risk of high cholesterol while taking this medication.
Tell your care team right away if you have any change in your eyesight.
Talk to your care team if you often see part of the tablet in your stool.
Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 4 weeks after the last dose. You will need a negative pregnancy test before starting this medication. Contraception is recommended while taking this medication and for 4 weeks after the last dose. Your care team can help you find the option that works for you.
Do not breastfeed while taking this medication and for 6 days after the last dose.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Keep this medication in the original container until you are ready to take it. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.