Warnings


What may interact with Zykadia?

Do not take this medicine with any of the following medications:

-alfuzosin
-certain medicines for cholesterol like lovastatin and simvastatin
-certain medicines for fungal infections like fluconazole, isavuconazonium, posaconazole, or voriconazole
-cisapride
-conivaptan
-dronedarone
-elitriptan
-eplerenone
-ergot alkaloids like dihydroergotamine and ergotamine
-flibanserin
-ivabradine
-lomitapide
-lurasidone
-naloxegol
-pimozide
-ranolazine
-saquinavir
-silodosin
-thioridazine
-tolvaptan
-triazolam
-ubrogepant
-venetoclax
This medicine may also interact with the following medications:

-alfentanil
-certain antiviral medicines for HIV or AIDS
-certain antibiotics like clarithromycin and telithromycin
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cyclosporine
-dofetilide
-fentanyl
-grapefruit juice
-nefazodone
-other medicines that prolong the QT interval (cause an abnormal heart rhythm)
-quinidine
-rifampin
-sirolimus
-St. John''s Wort
-tacrolimus
-warfarin
-ziprasidone

What should I tell my health care provider before I take Zykadia?

They need to know if you have any of these conditions:

-diabetes or high blood sugar
-heart disease
-history of irregular heartbeat
-history of pancreatitis
-liver disease
-low magnesium or potassium levels in the body
-lung or breathing disease, like asthma
-an unusual or allergic reaction to ceritinib, lactose, gelatin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using Zykadia?

Visit your doctor for checks on your progress. You will need to have regular blood tests while on this medicine. Report any new symptoms promptly.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body''s ability to fight infections. Try to avoid being around people who are sick.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Do not become pregnant while taking this medicine or for 6 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 3 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after the last dose.
This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Where should I keep my medicine?

Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.