Do not take this medication with any of the following:
-Cidofovir
-Ketorolac
This medication may also interact with the following:
-Alcohol
-Antacids
-Antihistamines for allergy, cough, and cold
-Aspirin and aspirin-like medications
-Certain medications for anxiety or sleep
-Certain medications for blood pressure, heart disease, irregular heart beat
-Certain medications for depression, such as amitriptyline, fluoxetine, sertraline
-Certain medications for diabetes, such as glipizide or glyburide
-Certain medications for seizures, such as phenobarbital, phenytoin, primidone
-Certain medications that treat or prevent blood clots, such as warfarin, enoxaparin, dalteparin, apixaban, dabigatran, rivaroxaban
-Cholestyramine
-Cyclosporine
-Digoxin
-Diuretics
-General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol
-Lithium
-Local anesthetics, such as lidocaine, pramoxine, tetracaine
-MAOIs, such as Carbex, Eldepryl, Marplan, Nardil, Parnate
-Medications that relax muscles for surgery
-Methotrexate
-Opioids for pain
-Other NSAIDs, medications for pain and inflammation, such as ibuprofen
-Pemetrexed
-Phenothiazines, such as chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-Probenecid
-Sucralfate

They need to know if you have any of these conditions:
-Coronary artery bypass graft (CABG) surgery within the past 2 weeks
-Frequently drink alcohol
-Glaucoma
-Heart disease
-High blood pressure
-History of stomach bleeding
-Kidney disease
-Liver disease
-Lung or breathing disease, such as asthma or COPD
-Tobacco use
-Trouble passing urine
-Prostate disease
-Stomach or intestine problems
-An unusual or allergic reaction to diphenhydramine, naproxen, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
Do not take other medications that contain aspirin, ibuprofen, or naproxen with this medication. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many non-prescription medications contain aspirin, ibuprofen, or naproxen. Always read labels carefully.
This medication can cause serious ulcers and bleeding in the stomach. It can happen with no warning. Tobacco or alcohol use, older age, and poor health can also increase risks. Call your care team right away if you have stomach pain or blood in your vomit or stool.
This medication does not prevent a heart attack or stroke. This medication may increase the chance of a heart attack or stroke. The chance may increase the longer you use this medication or if you have heart disease. If you take aspirin to prevent a heart attack or stroke, talk to your care team about using this medication.
This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medication.
This medication may make it more difficult to get pregnant. Talk to your care team if you are concerned about your fertility.

Keep out of the reach of children and pets.
Store between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.