-Alcohol
-Antihistamines for allergy, cough, or cold
-Certain antibiotics, such as erythromycin or clarithromycin
-Certain antivirals for HIV or hepatitis
-Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole
-Certain medications for mental health conditions
-Certain medications for seizures, such as carbamazepine, phenytoin, phenobarbital
-Conivaptan
-Diltiazem
-General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol
-Grapefruit juice
-Medications that relax muscles for surgery
-Opioid medications for pain
-Other medications for sleep
-Rifampin
-St. John's Wort
-Verapamil

They need to know if you have any of these conditions:
-Depression
-Frequently drink alcohol
-History of a sudden onset of muscle weakness (cataplexy)
-History of falling asleep often at unexpected times (narcolepsy)
-History of substance use disorder
-Liver disease
-Lung or breathing disease
-Sleep apnea
-Unusual sleep behaviors or activities you do not remember after taking a sleep medication
-Suicidal thoughts, plans, or attempt by you or a family member
-An unusual or allergic reaction to suvorexant, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Visit your care team for regular checks on your progress. Keep a regular sleep schedule by going to bed at about the same time each night. Avoid caffeine-containing drinks in the evening hours. Talk to your care team if your insomnia worsens or is not better within 7 to 10 days.
After taking this medication, you may get up out of bed and do an activity that you do not know you are doing. The next morning, you may have no memory of this. Activities include driving a car ("sleep-driving"), making and eating food, talking on the phone, sexual activity, and sleep-walking. Serious injuries have occurred. Stop the medication and call your care team right away if you find out you have done any of these activities. Do not take this medication if you have used alcohol that evening. Do not take it if you have taken another medication for sleep. The risk of doing these sleep-related activities is higher.
Do not take this medication unless you are able to stay in bed for a full night (7 to 8 hours) before you must be active again. Tell your care team if you will need to perform activities requiring full alertness, such as driving, the next day. You may have a decrease in mental alertness the day after use, even if you feel that you are fully awake. Do not stand or sit up quickly after taking this medication, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
If you or your family notice any changes in your moods or behavior, such as new or worsening depression, thoughts of harming yourself, anxiety, other unusual or disturbing thoughts, or memory loss, call your care team right away.
After you stop taking this medication, you may have trouble falling asleep. This is called rebound insomnia. This problem usually goes away on its own after 1 or 2 nights.

Keep out of the reach of children and pets. This medication can be abused. Keep it in a safe place to protect it from theft. Do not share it with anyone. It is only for you. Selling or giving away this medication is dangerous and against the law.
Store between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.
This medication may cause harm and death if it is taken by other adults, children, or pets. It is important to get rid of the medication as soon as you no longer need it or it is expired. You can do this in two ways:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.