What side effects may I notice from receiving Bosentan?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-rash, fever, and swollen lymph nodes
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
-swelling of the ankles, feet, hands

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

-facial flushing
-headache
-joint pain
-sore throat

This list may not describe all possible side effects for Bosentan. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.