Do not take this medication with any of the following:
-Adagrasib
-Certain antibiotics, such as erythromycin, clarithromycin, troleandomycin
-Certain antivirals for HIV or hepatitis
-Certain medications for fungal infections, such as fluconazole, ketoconazole, itraconazole, posaconazole
-Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
-Cocaine
-Conivaptan
-Dexfenfluramine
-Ergot alkaloids, such as dihydroergotamine, ergonovine, ergotamine, methylergonovine
-Ephedrine
-Feverfew
-Grapefruit juice
-Imatinib
-Isoproterenol
-Isosorbide
-Midodrine
-Nefazodone
-Nitroglycerin
-Phenylephrine
-Pseudoephedrine
This medication may also interact with the following:
-Certain medications for blood pressure, heart disease, irregular heartbeat
-Clotrimazole
-Fluoxetine
-Fluvoxamine
-Metronidazole
-Nicotine
-Zileuton

They need to know if you have any of these conditions:
-Heart or blood vessel disease
-High blood pressure
-Infection
-Kidney disease
-Liver disease
-Poor circulation
-An unusual or allergic reaction to ergotamine, caffeine, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Check with your care team if you do not get relief from your headaches after using this medication. You may need to be changed to a different kind of medication to treat your migraines.
This medication decreases the circulation of blood to your skin, fingers, and toes. You may get more sensitive to the cold. People older than 65 years are more likely to feel this effect. Dress warmly and avoid long exposure to the cold.
This medication contains caffeine. Limit your intake of caffeinated beverages on the days that you use this medication.
If you take migraine medications for 10 or more days a month, your migraines may get worse. Keep a diary of headache days and medication use. Contact your care team if your migraine attacks occur more frequently.

Keep out of the reach of children and pets.
Store between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find one.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.