-Certain antibiotics, such as chloramphenicol, clarithromycin, rifampin, rifapentine, telithromycin
-Certain antivirals for HIV or hepatitis
-Certain medications for cancer, such as apalutamide, ceritinib, enzalutamide, idelalisib, mitotane, ribociclib, tucatinib
-Certain medications for fungal infections, such as fluconazole, ketoconazole, itraconazole, posaconazole, voriconazole
-Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
-Certain medications for stomach problems, such as cimetidine, famotidine, lansoprazole, omeprazole, pantoprazole
-Diltiazem
-Grapefruit juice
-Lonafarnib
-Lumacaftor; ivacaftor
-Mifepristone
-Nefazodone
-St. John's Wort

They need to know if you have any of these conditions:
-Bleeding disorder
-Having or recent surgery
-Heart disease
-High blood pressure
-Infection
-Irregular heartbeat or rhythm
-Liver disease
-Take medications that treat or prevent blood clots
-An unusual or allergic reaction to acalabrutinib, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication.
You may need blood work while taking this medication.
This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
If you are going to need surgery or other procedure, tell your care team that you are using this medication.
Tell your dentist and dental surgeon that you are taking this medication. You should not have major dental surgery while on this medication. See your dentist to have a dental exam and fix any dental problems before starting this medication. Take good care of your teeth while on this medication. Make sure you see your dentist for regular follow-up appointments.
Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancer if you take this medication. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen.
Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 1 week after the last dose. You will need a negative pregnancy test before starting this medication. Contraception is recommended while taking this medication and for 1 week after the last dose. Your care team can help you find the option that works for you.
Do not breastfeed while taking this medication and for 2 weeks after the last dose.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.