Do not take this medication with any of the following:
-Metoclopramide
This medication may also interact with the following:
-Antihistamines for allergy, cough, and cold
-Aprepitant
-Armodafinil
-Bosentan
-Carbamazepine
-Certain antibiotics like ciprofloxacin, clarithromycin, erythromycin, nafcillin
-Certain antifungals like fluconazole, itraconazole, voriconazole
-Certain antivirals for HIV or hepatitis
-Certain medications for anxiety or sleep
-Certain medications for depression like amitriptyline, fluoxetine, nefazodone, sertraline
-Cyclosporine
-Fluvoxamine
-General anesthetics like halothane, isoflurane, methoxyflurane, propofol
-Grapefruit juice
-Levodopa or other medications for Parkinson's disease
-Medications for blood pressure
-Medications for seizures like phenytoin
-Medications that relax muscles for surgery
-Modafinil
-Narcotic medications for pain
-Phenothiazines like chlorpromazine, prochlorperazine, thioridazine
-Pioglitazone
-Prednisone
-Probenecid
-Rifampin
-St. John's Wort
-Valproic acid

They need to know if you have any of these conditions:
-Dementia
-Diabetes
-Difficulty swallowing
-Have trouble controlling your muscles
-Heart disease
-High cholesterol
-History of stroke
-Kidney disease
-Liver disease
-Low blood counts, like low white cell, platelet, or red cell counts
-Low blood pressure
-Parkinson's disease
-Seizures
-Suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
-An unusual or allergic reaction to lumateperone, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Tell your care team if symptoms do not start to get better or if they get worse. Do not suddenly stop taking this medication. You may develop a severe reaction. Your care team will tell you how much medication to take. If your care team wants you to stop the medication, the dose may be slowly lowered over time to avoid any side effects.
Watch for new or worsening thoughts of suicide or depression. This includes sudden changes in mood, behavior, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.
This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
This medication can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your care team right away.
Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.