Medically Reviewed by Harshi Dhingra, M.D.

Last Reviewed: Jun 22, 2022

Pros & Cons

What are the pros and cons of Cymbalta (duloxetine)?

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  • Cymbalta has several uses and may work well for people with multiple problems, such as depression and chronic pain.
  • It has less effect on blood pressure compared to other SNRIs.
  • It is available as a low-cost generic. Cymbalta coupons can result in average savings of $40 or more.

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  • Cymbalta can take up to 12 weeks for full effect. 
  • This medicine may not be a good option for heavy drinkers or people with heart disease, liver disease, or kidney disease.
  • In a small number of children, teens, and young adults, it can cause suicidal thoughts and behaviors.