Do not take this medication with any of the following:
-Linezolid
-MAOIs, such as Marplan, Nardil, and Parnate
-Methylene blue (injected into a vein)
This medication may also interact with the following:
-Alcohol
-Aspirin and aspirin-like medications
-Certain medications for depression, anxiety, or other mental health conditions
-Certain medications for migraines, such as sumatriptan
-Medications that treat or prevent blood clots, such as warfarin, enoxaparin, dalteparin
-NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
-Opioids
-Stimulant medications for ADHD, weight loss, or staying awake
-St. John's wort
-Tryptophan

They need to know if you have any of these conditions:
-Glaucoma
-High blood pressure
-Kidney disease
-Liver disease
-Mania or bipolar disorder
-Suicidal thoughts, plans, or attempt
-An unusual reaction to desvenlafaxine, venlafaxine, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication.
This medication may cause thoughts of suicide or depression. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.
The medication may cause increased blood pressure. Check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.