Doxycycline Monohydrate

( Oracea )

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Apr 26, 2023

Pharmacist Tips


Doxycycline Monohydrate Tips from Pharmacists

  • Take doxycycline monohydrate with a full glass of water to avoid irritation of the esophagus (food pipe).

  • If you are taking Oracea, take it on an empty stomach in the morning, 1 hour before or two hours after meals.

  • If you are taking the syrup (Vibramycin), use a dose measuring cup or syringe to carefully measure the dose. Do not use a regular kitchen spoon.

  • If you are taking products containing calcium, aluminum, or magnesium, such as antacids, calcium supplements, or laxatives, take them 1-2 hours away from doxycycline monohydrate. Take iron products 2-3 hours away from the antibiotic.

  • Wear protective clothing and sunscreen and avoid unnecessary exposure to sunlight.

  • Doxycycline monohydrate can lower the effectiveness of hormonal birth control. Talk to your doctor about other methods of birth control to prevent pregnancy.

  • Tell your doctor immediately if you develop severe diarrhea up to 2 months after treatment with this drug.