-Amiodarone
-Antacids
-Certain antibiotics, such as rifabutin, rifampin, rifapentine
-Certain medications for cholesterol, such as atorvastatin or rosuvastatin
-Certain medications for diabetes
-Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
-Certain medications for stomach problems, such as cimetidine, famotidine, omeprazole, lansoprazole
-Digoxin
-Efavirenz
-St. John's wort
-Tipranavir
-Topotecan
-Warfarin

They need to know if you have any of these conditions:
-Diabetes
-Heart disease
-HIV or AIDS
-Organ transplant
-Other liver disease
-An unusual or allergic reaction to sofosbuvir, velpatasvir, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. You may need blood work while you are taking this medication.
If you have had hepatitis B in the past, talk to your care team. Taking this medication could cause the hepatitis B virus to become active again.
This medication may cause changes in your blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.
Talk to your care team if you are pregnant or think you might be pregnant. Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.

Keep out of the reach of children and pets.
Store below 30 degrees C (86 degrees F). Keep this medication in the original packaging until you are ready to take it. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.