Warnings


What may interact with Epidiolex Solution?

Do not take this medication with any of the following:
-Fezolinetant
This medication may also interact with the following:
-Alcohol
-Benzodiazepines, such as alprazolam, diazepam, lorazepam
-Certain antihistamines
-Certain medications for depression, such as amitriptyline or trazodone
-Certain medications for seizures, such as clobazam, phenobarbital, primidone, valproic acid
-Everolimus
-Medications that cause drowsiness before a procedure, such as propofol
-Medications that help you fall asleep
-Medications that relax muscles
-Opioids for pain or cough
-Phenothiazines, such as chlorpromazine, prochlorperazine, thioridazine
-Sirolimus
-Tacrolimus
This medication may affect how other medications work, and other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

What should I tell my health care provider before I take Epidiolex Solution

They need to know if you have any of these conditions:
-Liver disease
-Mental health condition
-Suicidal thoughts, plans, or attempt
-An unusual or allergic reaction to cannabidiol, sesame seed oil, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

What should I watch for while using Epidiolex Solution?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Watch for new or worsening thoughts of suicide or depression. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.

Where should I keep my medicine?

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Keep the container tightly closed. Get rid of any unused medication 12 weeks after opening.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, pour the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.