Do not take this medication with any of the following:
-Artemether; Lumefantrine
-Certain antivirals for HIV or hepatitis
-Isavuconazonium
-Lonafarnib
-Lorlatinib
-Lurasidone
-Mavacamten
-Pacritinib
-Praziquantel
-Ranolazine
-Voriconazole
This medication may also interact with the following:
-Gemfibrozil
-Itraconazole
-Ketoconazole
-Midazolam
-Omeprazole
-Rifampin
-Warfarin

They need to know if you have any of these conditions:
-Brain tumor
-Diabetes
-Head injury
-Heart disease
-High blood pressure
-High cholesterol
-Osteoporosis, weak bones
-Seizures
-Stroke
-An unusual or allergic reaction to apalutamide, other medications, foods, dyes, or preservatives
-If you or your partner are pregnant or trying to get pregnant
-Breastfeeding

This medication may make you feel generally unwell. This is not uncommon as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop.
Using this medication for a long time may weaken your bones. The risk of bone fractures may be increased. Talk to your care team about your bone health.
This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.
Heart attacks and strokes have been reported with the use of this medication. Get emergency help if you develop signs or symptoms of a heart attack or stroke. Talk to your care team about the risks and benefits of this medication.
If your partner can get pregnant, use a condom during sex while taking this medication and for 3 months after the last dose. Tell your care team right away if you think your partner might be pregnant. This medication can cause serious birth defects.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.
Do not donate sperm while taking this medication and for 3 months after the last dose.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original packaging. Protect from moisture. Keep the container tightly closed. Do not throw out the packet in the container. It keeps the medication dry. Protect from light. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.