Do not take this medication with any of the following:
-Bosentan
-Certain contrast agents used before, CT, MRI, or X-ray scans
This medication may also interact with the following:
-Acetazolamide
-Alcohol
-Chloramphenicol
-Cimetidine
-Colesevelam
-Dichlorphenamide
-Dolutegravir
-Probenecid
-Ranolazine
-Topiramate
-Vandetanib
-Zonisamide
Some medications may affect your blood sugar levels or hide the symptoms of low blood sugar (hypoglycemia). Talk with your care team about all the medications you take. They may suggest checking your blood sugar levels more often.
Medications that may affect your blood sugar levels include:
-Alcohol
-Certain antibiotics, such as ciprofloxacin, levofloxacin, sulfamethoxazole; trimethoprim
-Certain medications for blood pressure or heart disease, such as benazepril, enalapril, lisinopril, losartan, valsartan
-Certain medications for mental health conditions, such as fluoxetine or olanzapine
-Diuretics, such as hydrochlorothiazide (HCTZ)
-Estrogen and progestin hormones
-Other medications for diabetes
-Steroid medications, such as prednisone or cortisone
-Testosterone
-Thyroid hormones
Medications that may mask symptoms of low blood sugar include:
-Beta-blockers, such as atenolol, metoprolol, propranolol
-Clonidine
-Guanethidine
-Reserpine

They need to know if you have any of these conditions:
-Dehydration
-Frequently drink alcohol
-G6PD deficiency
-Have had diabetic ketoacidosis (DKA)
-Having a CT or X-ray scan
-Having surgery
-Heart attack
-Heart disease
-Infection
-Irregular menstrual cycles
-Kidney disease
-Liver disease
-Low levels of calcium in your blood
-Low levels of vitamin B in your blood
-Stroke
-An unusual or allergic reaction to glyburide, metformin, sulfa medications, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
You may need blood work done while you are taking this medication. Your care team will monitor your HbA1C (A1C). This test shows what your average blood sugar (glucose) level was over the past 2 to 3 months.
Know the symptoms of low blood sugar and know how to treat it. Always carry a source of quick sugar with you. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink if your blood sugar is too low and you are unable to care for yourself. Get medical help at once.
Tell your care team if you have high blood sugar. Your medication dose may change if your body is under stress. Some types of stress that may affect your blood sugar include fever, infection, and surgery.
Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.
Make sure you stay hydrated while taking this medication. Drink water often. Eat fruits and veggies that have a high water content. Drink more water when it is hot or you are active. Talk to your care team right away if you have fever, infection, vomiting, diarrhea, or if you sweat a lot while taking this medication. The loss of too much body fluid may make it dangerous for you to take this medication.
Tell your care team you are taking this medication before you have surgery or an imaging scan, such as a CT or X-ray. You may need to stop taking this medication for a while before and after the procedure. Your care team will tell you when to stop and when to start taking it again.
Make sure you get enough vitamin B12 while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.
This medication may cause you to ovulate, which may increase your chances of becoming pregnant. Talk with your care team about contraception while you are taking this medication. Contact your care team if you think you might be pregnant.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.