Guaifenesin

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Dec 13, 2022

Common Questions


Common Questions about Guaifenesin


Does guaifenesin work immediately?

Guaifenesin starts working quickly, usually within 30 minutes of a dose. You should notice an improvement in your symptoms for up to 6 hours after taking the immediate-release forms and up to 12 hours after taking the extended-release forms. It can take up to 2 days, however, to get the full benefits of this medicine.



Does guaifenesin affect sleep?

Guaifenesin does not affect sleep. However, other ingredients in combination products may affect sleep if taken at bedtime. Check the label. Ask your doctor or pharmacist if you’re not sure whether any of the ingredients in your cough and cold medicine can affect sleep.



Does guaifenesin dry you out?

Guaifenesin does not dry you out. It helps clear mucus from your airways and makes it easier to breathe. However, cough and cold remedies often contain antihistamines and/or decongestants in addition to guaifenesin. These combination products can be extremely drying. Be sure to drink plenty of fluid when taking cough and cold medicines to stay well hydrated.



Does guaifenesin help with COVID?

Most people with COVID develop a dry cough. Guaifenesin works by loosening mucus and is more effective for wet coughs. However, guaifenesin may make breathing easier by clearing congestion if mucus is present during COVID.



Does guaifenesin raise blood pressure?

Guaifenesin is an expectorant and is not known to increase blood pressure. Most people tolerate this medicine well without major side effects.



What is the price of guaifenesin without insurance? 

Without insurance, guaifenesin can be as high as $22.00, but with a free BuzzRx prescription discount coupon, you could pay as low as $6.45 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not.