Do not take this medication with any of the following:
-Certain medications for erectile dysfunction (ED), such as avanafil, sildenafil, tadalafil, or vardenafil
-Riociguat
This medication may also interact with the following:
-Medications for high blood pressure
-Other medications for angina or heart failure

They need to know if you have any of these conditions:
-Previous heart attack or heart failure
-An unusual or allergic reaction to isosorbide dinitrate, nitrates, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Check your heart rate and blood pressure as directed. Know what your heart rate and blood pressure should be and when to contact your care team. Tell your care team if you feel your medication is no longer working.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Do not treat yourself for coughs, colds, or pain while you are taking this medication without asking your care team for advice. Some medications may increase your blood pressure.

Keep out of the reach of children.
Store at room temperature, approximately 25 degrees C (77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medication after the expiration date.