-Interactions have not been studied.

They need to know if you have any of these conditions:
-Diarrhea
-History of blockage in your bowels
-History of stool (fecal) impaction
-An unusual or allergic reaction to linaclotide, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
Diarrhea is a common side effect of this medication. It often begins within 2 weeks of starting this medication. Stop taking this medication and call your care team if you get severe diarrhea.
Stop taking this medication and call your care team or go to the nearest hospital emergency room right away if you develop unusual or severe stomach pain, especially if you also have bright red, bloody stools or black stools that look like tar.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original container. Protect from moisture. Keep the container tightly closed. Do not throw out the packet in the container. It keeps the medication dry. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.