Do not take this medication with any of the following:
-Aromatase inhibitors, such as aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
-Cisapride
-Dronedarone
-Elagolix
-Pimozide
-Thioridazine
This medication may also interact with the following:
-Certain antibiotics, such as erythromycin, clarithromycin, telithromycin
-Certain antivirals for HIV or hepatitis
-Certain medications for cancer treatment
-Certain medications for fungal infections, such as ketoconazole, itraconazole, posaconazole
-Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
-Corticosteroids, such as hydrocortisone, prednisone, prednisolone
-Cyclosporine
-Grapefruit juice
-Medications for diabetes
-Mifepristone
-Other medications that cause heart rhythm changes
-Raloxifene
-Rifampin
-St. John's wort
-Tamoxifen
-Thyroid hormones
-Tranexamic acid
-Tricyclic antidepressants
-Verapamil
-Warfarin

They need to know if you have any of these conditions:
-Blood clots
-Breast, cervical, endometrial, or uterine cancer
-Diabetes
-Gallbladder disease
-Heart disease
-High blood pressure
-High cholesterol
-Kidney disease
-Liver disease
-Lupus
-Mental health condition
-Migraine headaches
-Osteoporosis, weak bones
-Porphyria
-Stroke
-Suicidal thoughts, plans, or attempt by you or a family member
-Tobacco use
-Unexplained vaginal bleeding
-An unusual or allergic reaction to relugolix, estrogens, progestins, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Visit your care team for regular checks on your progress. You will need a regular breast and pelvic exam while on this medication. It may take several months to see improvement in your condition.
You may have a change in bleeding pattern, irregular periods, or may stop having periods while taking this medication.
Talk with your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 1 week after the last dose. Contraception is recommended while taking this medication and for 1 week after the last dose. Your care team can help you find the option that works for you.
Talk to your care team if you use tobacco products. Changes to your treatment plan may be needed. Tobacco increases the risk of getting a blood clot or having a stroke while taking this medication. The risk is higher if you are over the age of 35.
This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.
Using this medication for a long time may weaken your bones. The risk of bone fractures may be increased. Talk to your care team about your bone health.
If you are going to need surgery or other procedure, tell your care team that you are using this medication.

Keep out of the reach of children and pets.
Store between 15 and 30 degrees C (59 and 86 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.