Do not take this medication with any of the following:
-Aromatase inhibitors, such as aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
-Cyclosporine
-Enasidenib
-Gemfibrozil
-Trofinetide
This medication may also interact with the following:
-Benzodiazepines
-Bosentan
-Bromocriptine
-Certain antivirals for HIV or hepatitis
-Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
-Cimetidine
-Citalopram
-Dantrolene
-Digoxin
-Estrogen or progestin hormones
-Grapefruit juice
-Griseofulvin
-Hydrocortisone, cortisone, or prednisolone
-Isoniazid (INH)
-Medications for diabetes
-Methadone
-Methotrexate
-Midazolam
-Mineral oil
-Omeprazole
-Raloxifene
-Rifabutin, rifampin, or rifapentine
-Rosuvastatin
-Tamoxifen
-Thyroid hormones
-Topiramate
-Tricyclic antidepressants
-Warfarin

They need to know if you have any of these conditions:
-Blood vessel disease or blood clots
-Breast, cervical, endometrial, or uterine cancer
-Diabetes (high blood sugar)
-Gallbladder disease
-Heart disease
-High blood pressure
-High cholesterol
-Kidney disease
-Liver disease
-Lupus
-Mental health conditions
-Migraine headaches
-Osteoporosis, weak bones
-Porphyria
-Stroke
-Suicidal thoughts, plans, or attempt by you or a family member
-Tobacco use
-Unexplained vaginal bleeding
-An unusual or allergic reaction to elagolix, estrogens, progestins, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. You will need a regular breast and pelvic exam while on this medication. It may take several cycles of use to see improvement in your condition.
You may have a change in bleeding pattern or irregular periods. Many patients stop having periods while taking this medication.
Talk to your care team if you use tobacco products. Changes to your treatment plan may be needed. Tobacco increases the risk of getting a blood clot or having a stroke while you are taking this medication. This risk is higher if you are over the age of 35.
This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.
This medication may cause weak bones (osteoporosis). Only use this product for the amount of time your care team tells you to. The longer you use this product, the more likely you will be at risk for weak bones. Ask your care team how you can keep strong bones.
Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects. Estrogen and/or progestin hormones may not work as well while you are taking this medication. A barrier contraceptive, such as a condom or diaphragm, is recommended during and for 28 days after stopping treatment. Talk to your care team about other forms of contraception.
If you are going to need surgery or other procedure, tell your care team that you are using this medication.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your care team.
Using this medication does not protect you or your partner against HIV or other sexually transmitted infections (STIs).

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.