Warnings


What may interact with Prempro?

-Barbiturates, such as phenobarbital
-Benzodiazepines
-Bosentan
-Bromocriptine
-Carbamazepine
-Cimetidine
-Cyclosporine
-Dantrolene
-Grapefruit juice
-Griseofulvin
-Hydrocortisone, cortisone, or prednisolone
-Isoniazid (INH)
-Medications for diabetes
-Methotrexate
-Mineral oil
-Phenytoin
-Raloxifene
-Rifabutin, rifampin, or rifapentine
-Tamoxifen
-Thyroid hormones
-Topiramate
-Tricyclic antidepressants
-Warfarin

What should I tell my health care provider before I take Prempro

They need to know if you have any of these conditions:
-Blood vessel disease or blood clots
-Breast, cervical, endometrial, or uterine cancer
-Depression
-Diabetes
-Endometriosis
-Fibroids
-Gallbladder disease
-Heart disease or recent heart attack
-High blood cholesterol
-High blood pressure
-High level of calcium in the blood
-Hysterectomy
-Kidney disease
-Liver disease
-Migraine headaches
-Porphyria
-Protein C deficiency
-Protein S deficiency
-Stroke
-Systemic lupus erythematosus (SLE)
-Tobacco use
-Vaginal bleeding
-An unusual or allergic reaction to estrogens, progestins, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

What should I watch for while using Prempro?

Visit your care team for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your care team, and follow their guidelines.
This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medication at once and contact your care team.
Talk to your care team if you use tobacco products. Changes to your treatment plan may be needed. Tobacco increases the risk of getting a blood clot or having a stroke while you are taking this medication. This risk is higher if you are over the age of 35.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your care team.
If you are going to have elective surgery, you may need to stop taking this medication beforehand. Consult your care team for advice prior to scheduling the surgery.

Where should I keep my medicine?

Keep out of the reach of children and pet.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.