Do not take this medication with any of the following:
-Acitretin
-Probenecid
This medication may also interact with the following:
-Aspirin and aspirin-like medications
-Azathioprine
-Certain antibiotics, such as chloramphenicol, gentamicin, penicillin, sulfamethoxazole; trimethoprim, tetracycline, vancomycin
-Certain medications that prevent or treat blood clots, such as warfarin, apixaban, dabigatran, rivaroxaban
-Certain medications for stomach problems, such as esomeprazole, omeprazole, pantoprazole
-Cyclosporine
-Dapsone
-Diuretics
-Hydroxychloroquine
-Live virus vaccines
-Mercaptopurine
-NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
-Oral retinoids, such as isotretinoin or tretinoin
-Phenytoin
-Steroid medications, such as prednisone or cortisone
-Sulfasalazine
-Theophylline

They need to know if you have any of these conditions:
-Fluid in the stomach area or abdomen
-Frequently drink alcohol
-Immune system conditions
-Inflammatory bowel disease, such as ulcerative colitis
-Kidney disease
-Liver disease
-Low blood cell levels (white cells, red cells, and platelets)
-Lung disease
-Recent or ongoing radiation therapy
-Stomach ulcers, other stomach or intestine problems
-An unusual or allergic reaction to methotrexate, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Avoid alcoholic drinks.
This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
You may need blood work done while you are taking this medication.
Call your care team for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This medication decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.
Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medication
Check with your care team if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medication.
Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancers if you take this medication.
Do not become pregnant while taking this medication or for 6 months after stopping it. Women should inform their care team if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medication and for 3 months after stopping it. There is potential for serious harm to an unborn child. Talk to your care team for more information. Do not breast-feed an infant while taking this medication or for 1 week after stopping it.
This medication may make it more difficult to get pregnant or father a child. Talk to your care team if you are concerned about your fertility.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Get rid of any unused medication after the expiration date.
Talk to your care team about how to dispose of unused medicine. Special directions may apply.